Are alterations in transmitter receptor and ion channel expression responsible for epilepsies?

Kim L. Powell, Katarzyna Lukasiuk, Terence J. O'Brien, Asla Pitkänen

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

7 Citations (Scopus)

Abstract

Neuronal voltage-gated ion channels and ligand-gated synaptic receptors play a critical role in maintaining the delicate balance between neuronal excitation and inhibition within neuronal networks in the brain. Changes in expression of voltage-gated ion channels, in particular sodium, hyperpolarization- activated cyclic nucleotide- gated (HCN) and calcium channels, and ligand-gated synaptic receptors, in particular GABA and glutamate receptors, have been reported in many types of both genetic and acquired epilepsies, in animal models and in humans. In this chapter we review these and discuss the potential pathogenic role they may play in the epilepsies.

Original languageEnglish
Title of host publicationIssues in Clinical Epileptology
Subtitle of host publicationA View from the Bench
PublisherSpringer
Pages211-229
Number of pages19
Volume813
ISBN (Print)9789401789134
DOIs
Publication statusPublished - 2014
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume813
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Acquired epilepsy
  • Animal models of epilepsy
  • Genetic generalized epilepsy
  • Ligand-gated ion channels
  • Voltage-gated ion channels

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