Are alterations in skeletal muscle mitochondria a cause or consequence of insulin resistance?

Amanda J. Genders, Graham P. Holloway, David J. Bishop

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29 Citations (Scopus)


As a major site of glucose uptake following a meal, skeletal muscle has an important role in whole-body glucose metabolism. Evidence in humans and animal models of insulin resistance and type 2 diabetes suggests that alterations in mitochondrial characteristics accompany the development of skeletal muscle insulin resistance. However, it is unclear whether changes in mitochondrial content, respiratory function, or substrate oxidation are central to the development of insulin resistance or occur in response to insulin resistance. Thus, this review will aim to evaluate the apparent conflicting information placing mitochondria as a key organelle in the development of insulin resistance in skeletal muscle.

Original languageEnglish
Article number6948
Number of pages25
JournalInternational Journal of Molecular Sciences
Issue number18
Publication statusPublished - Sept 2020
Externally publishedYes


  • Fatty acid oxidation
  • Insulin resistance
  • Lipid metabolites
  • Mitochondria
  • Mitochondrial content
  • Mitochondrial function
  • Skeletal muscle
  • Type 2 diabetes

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