Arbidol: A potential antiviral drug for the treatment of SARS-CoV-2 by blocking the trimerization of viral spike glycoprotein?

Naveen Vankadari

doi:10.1016/j.ijantimicag.2020.105998

Arbidol: A potential antiviral drug for the treatment of SARS-CoV-2 by blocking the trimerization of viral spike glycoprotein?

Naveen Vankadari

Research output: Contribution to journal › Article › Research › peer-review

224 Citations (Scopus)

Abstract

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic is a global public health emergency, and new therapeutics are needed. This article reports the potential drug target and mechanism of action of Arbidol (umifenovir) to treat coronavirus disease 2019 (COVID-19). Molecular dynamics and structural analysis were used to show how Arbidol targets the SARS-CoV-2 spike glycoprotein and impedes its trimerization, which is key for host cell adhesion and hijacking, indicating the potential of Arbidol to treat COVID-19. It is hoped that knowledge of the potential drug target and mechanism of action of Arbidol will help in the development of new therapeutics for SARS-CoV-2.

Original language	English
Article number	105998
Number of pages	3
Journal	International Journal of Antimicrobial Agents
Volume	56
Issue number	2
DOIs	https://doi.org/10.1016/j.ijantimicag.2020.105998
Publication status	Published - Aug 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Antiviral
Coronavirus
COVID-19
Molecular dynamics
Spike glycoprotein

Access to Document

10.1016/j.ijantimicag.2020.105998

Cite this

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title = "Arbidol: A potential antiviral drug for the treatment of SARS-CoV-2 by blocking the trimerization of viral spike glycoprotein?",

abstract = "The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic is a global public health emergency, and new therapeutics are needed. This article reports the potential drug target and mechanism of action of Arbidol (umifenovir) to treat coronavirus disease 2019 (COVID-19). Molecular dynamics and structural analysis were used to show how Arbidol targets the SARS-CoV-2 spike glycoprotein and impedes its trimerization, which is key for host cell adhesion and hijacking, indicating the potential of Arbidol to treat COVID-19. It is hoped that knowledge of the potential drug target and mechanism of action of Arbidol will help in the development of new therapeutics for SARS-CoV-2.",

keywords = "Antiviral, Coronavirus, COVID-19, Molecular dynamics, Spike glycoprotein",

author = "Naveen Vankadari",

year = "2020",

month = aug,

doi = "10.1016/j.ijantimicag.2020.105998",

language = "English",

volume = "56",

journal = "International Journal of Antimicrobial Agents",

issn = "0924-8579",

publisher = "Elsevier BV",

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TY - JOUR

T1 - Arbidol

T2 - A potential antiviral drug for the treatment of SARS-CoV-2 by blocking the trimerization of viral spike glycoprotein?

AU - Vankadari, Naveen

PY - 2020/8

Y1 - 2020/8

N2 - The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic is a global public health emergency, and new therapeutics are needed. This article reports the potential drug target and mechanism of action of Arbidol (umifenovir) to treat coronavirus disease 2019 (COVID-19). Molecular dynamics and structural analysis were used to show how Arbidol targets the SARS-CoV-2 spike glycoprotein and impedes its trimerization, which is key for host cell adhesion and hijacking, indicating the potential of Arbidol to treat COVID-19. It is hoped that knowledge of the potential drug target and mechanism of action of Arbidol will help in the development of new therapeutics for SARS-CoV-2.

AB - The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic is a global public health emergency, and new therapeutics are needed. This article reports the potential drug target and mechanism of action of Arbidol (umifenovir) to treat coronavirus disease 2019 (COVID-19). Molecular dynamics and structural analysis were used to show how Arbidol targets the SARS-CoV-2 spike glycoprotein and impedes its trimerization, which is key for host cell adhesion and hijacking, indicating the potential of Arbidol to treat COVID-19. It is hoped that knowledge of the potential drug target and mechanism of action of Arbidol will help in the development of new therapeutics for SARS-CoV-2.

KW - Antiviral

KW - Coronavirus

KW - COVID-19

KW - Molecular dynamics

KW - Spike glycoprotein

UR - https://www.scopus.com/pages/publications/85084429953

U2 - 10.1016/j.ijantimicag.2020.105998

DO - 10.1016/j.ijantimicag.2020.105998

M3 - Article

AN - SCOPUS:85084429953

SN - 0924-8579

VL - 56

JO - International Journal of Antimicrobial Agents

JF - International Journal of Antimicrobial Agents

IS - 2

M1 - 105998

ER -

Arbidol: A potential antiviral drug for the treatment of SARS-CoV-2 by blocking the trimerization of viral spike glycoprotein?

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Emerging WuHan (COVID-19) coronavirus: glycan shield and structure prediction of spike glycoprotein and its interaction with human CD26

Structural interactions between pandemic SARS-CoV-2 spike glycoprotein and human Furin protease

Australian scientists have uncovered the mechanism of action of Arbidol on the coronavirus SARS-CoV-2

Monash eResearch

Cite this

Arbidol: A potential antiviral drug for the treatment of SARS-CoV-2 by blocking the trimerization of viral spike glycoprotein?

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Research output

Emerging WuHan (COVID-19) coronavirus: glycan shield and structure prediction of spike glycoprotein and its interaction with human CD26

Structural interactions between pandemic SARS-CoV-2 spike glycoprotein and human Furin protease

Press/Media

Australian scientists have uncovered the mechanism of action of Arbidol on the coronavirus SARS-CoV-2

Equipment

Monash eResearch

Cite this