TY - JOUR
T1 - Arabinoxylan-Carboxymethylcellulose composite films for antibiotic delivery to infected wounds
AU - Alruwaili, Nabil K.
AU - Ahmad, Naveed
AU - Alzarea, Abdulaziz I.
AU - Alomar, Fadhel A.
AU - Alquraini, Ali
AU - Akhtar, Sultan
AU - Bin Shahari, Muhammad Syafiq
AU - Zafar, Ameeduzzafar
AU - Elmowafy, Mohammed
AU - Elkomy, Mohammed H.
AU - Dolzhenko, Anton V.
AU - Iqbal, Mohammad Saeed
N1 - Funding Information:
Funding: This research was funded by Deanship of Scientific Research at Jouf University through grant number grant no. DSR 40/32. The APC was funded by Jouf University.
Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/5/1
Y1 - 2022/5/1
N2 - Modern dressings should provide for local delivery of antibiotics and protect the wound from bacterial infection, dehydration and environmental factors to achieve optimal healing. The local delivery of antibiotics can reduce adverse effects and resistance challenges. In this study, we fabricated film dressings composed of arabinoxylan (AX) from Plantago ovata seed husks and carboxymethylcellulose (CMC) by a solvent cast method for the delivery of the antibiotic amikacin (AMK). To determine the suitability of the prepared AX-CMC composite films as wound dressings and drug delivery materials, their physical, chemical, mechanical, morphological, thermal, pharmaceutical, antimicrobial, cytocompatible, and drug delivery properties were investigated. The results demonstrated that the dressings were suitable for delivering the drug at the wound site in a sustained manner and keeping the environment moist for rapid healing. The AMK-loaded AX-CMC films exhibited controlled release of AMK, excellent antibacterial activity, and cytocompatibility. Thus, the AX-CMC composite films appear to be promising bioactive dressing materials for the prevention of wound infections.
AB - Modern dressings should provide for local delivery of antibiotics and protect the wound from bacterial infection, dehydration and environmental factors to achieve optimal healing. The local delivery of antibiotics can reduce adverse effects and resistance challenges. In this study, we fabricated film dressings composed of arabinoxylan (AX) from Plantago ovata seed husks and carboxymethylcellulose (CMC) by a solvent cast method for the delivery of the antibiotic amikacin (AMK). To determine the suitability of the prepared AX-CMC composite films as wound dressings and drug delivery materials, their physical, chemical, mechanical, morphological, thermal, pharmaceutical, antimicrobial, cytocompatible, and drug delivery properties were investigated. The results demonstrated that the dressings were suitable for delivering the drug at the wound site in a sustained manner and keeping the environment moist for rapid healing. The AMK-loaded AX-CMC films exhibited controlled release of AMK, excellent antibacterial activity, and cytocompatibility. Thus, the AX-CMC composite films appear to be promising bioactive dressing materials for the prevention of wound infections.
KW - antibiotic delivery
KW - arabinoxylan
KW - carboxymethylcellulose
KW - film dressing
KW - infected wound
UR - http://www.scopus.com/inward/record.url?scp=85129821032&partnerID=8YFLogxK
U2 - 10.3390/polym14091769
DO - 10.3390/polym14091769
M3 - Article
C2 - 35566937
AN - SCOPUS:85129821032
SN - 2073-4360
VL - 14
JO - Polymers
JF - Polymers
IS - 9
M1 - 1769
ER -