Aqueous ROPISA of α-amino acid: N -carboxyanhydrides: Polypeptide block secondary structure controls nanoparticle shape anisotropy

Chloé Grazon, Pedro Salas-Ambrosio, Ségolène Antoine, Emmanuel Ibarboure, Olivier Sandre, Andrew J. Clulow, Ben J. Boyd, Mark W. Grinstaff, Sébastien Lecommandoux, Colin Bonduelle

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)


Polymerization-induced self-assembly (PISA) is an efficient one-step process to obtain nanomaterials. In this work, aqueous ring-opening polymerization induced self-assembly (ROPISA) of α-amino acid N-carboxyanhydride (NCA) affords controllable well-defined nanoassemblies. ROPISA with the PEG5 kDa-NH2 macroinitiator and either the benzyl-l-glutamate NCA (BLGNCA) or l-leucine NCA (LeuNCA) monomer yields amphiphilic block copolymers, with different polypeptide molar masses, which spontaneously form nanostructures. In contrast to the previous PISA process where the hydrophobic to hydrophilic ratio was the main parameter defining nanomaterial morphology, the secondary structure of the polypeptides is the main driving force to stabilize the anisotropic rod-like nanostructures with this ROPISA process. This journal is

Original languageEnglish
Pages (from-to)6242-6251
Number of pages10
JournalPolymer Chemistry
Issue number43
Publication statusPublished - 21 Nov 2021

Cite this