Aqueous ROPISA of α-amino acid: N -carboxyanhydrides: Polypeptide block secondary structure controls nanoparticle shape anisotropy

Chloé Grazon; Pedro Salas-Ambrosio; Ségolène Antoine; Emmanuel Ibarboure; Olivier Sandre; Andrew J. Clulow; Ben J. Boyd; Mark W. Grinstaff; Sébastien Lecommandoux; Colin Bonduelle

doi:10.1039/d1py00995h

Aqueous ROPISA of α-amino acid: N -carboxyanhydrides: Polypeptide block secondary structure controls nanoparticle shape anisotropy

Chloé Grazon, Pedro Salas-Ambrosio, Ségolène Antoine, Emmanuel Ibarboure, Olivier Sandre, Andrew J. Clulow, Ben J. Boyd, Mark W. Grinstaff, Sébastien Lecommandoux, Colin Bonduelle

Drug Delivery Disposition & Dynamics

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Abstract

Polymerization-induced self-assembly (PISA) is an efficient one-step process to obtain nanomaterials. In this work, aqueous ring-opening polymerization induced self-assembly (ROPISA) of α-amino acid N-carboxyanhydride (NCA) affords controllable well-defined nanoassemblies. ROPISA with the PEG5 kDa-NH2 macroinitiator and either the benzyl-l-glutamate NCA (BLGNCA) or l-leucine NCA (LeuNCA) monomer yields amphiphilic block copolymers, with different polypeptide molar masses, which spontaneously form nanostructures. In contrast to the previous PISA process where the hydrophobic to hydrophilic ratio was the main parameter defining nanomaterial morphology, the secondary structure of the polypeptides is the main driving force to stabilize the anisotropic rod-like nanostructures with this ROPISA process. This journal is

Original language	English
Pages (from-to)	6242-6251
Number of pages	10
Journal	Polymer Chemistry
Volume	12
Issue number	43
DOIs	https://doi.org/10.1039/d1py00995h
Publication status	Published - 21 Nov 2021

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10.1039/d1py00995h

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Grazon, Chloé ; Salas-Ambrosio, Pedro ; Antoine, Ségolène ; Ibarboure, Emmanuel ; Sandre, Olivier ; Clulow, Andrew J. ; Boyd, Ben J. ; Grinstaff, Mark W. ; Lecommandoux, Sébastien ; Bonduelle, Colin. / Aqueous ROPISA of α-amino acid : N -carboxyanhydrides: Polypeptide block secondary structure controls nanoparticle shape anisotropy. In: Polymer Chemistry. 2021 ; Vol. 12, No. 43. pp. 6242-6251.

@article{b33b421514d8485caa1568fdb4c448c6,

title = "Aqueous ROPISA of α-amino acid: N -carboxyanhydrides: Polypeptide block secondary structure controls nanoparticle shape anisotropy",

abstract = "Polymerization-induced self-assembly (PISA) is an efficient one-step process to obtain nanomaterials. In this work, aqueous ring-opening polymerization induced self-assembly (ROPISA) of α-amino acid N-carboxyanhydride (NCA) affords controllable well-defined nanoassemblies. ROPISA with the PEG5 kDa-NH2 macroinitiator and either the benzyl-l-glutamate NCA (BLGNCA) or l-leucine NCA (LeuNCA) monomer yields amphiphilic block copolymers, with different polypeptide molar masses, which spontaneously form nanostructures. In contrast to the previous PISA process where the hydrophobic to hydrophilic ratio was the main parameter defining nanomaterial morphology, the secondary structure of the polypeptides is the main driving force to stabilize the anisotropic rod-like nanostructures with this ROPISA process. This journal is ",

author = "Chlo{\'e} Grazon and Pedro Salas-Ambrosio and S{\'e}gol{\`e}ne Antoine and Emmanuel Ibarboure and Olivier Sandre and Clulow, {Andrew J.} and Boyd, {Ben J.} and Grinstaff, {Mark W.} and S{\'e}bastien Lecommandoux and Colin Bonduelle",

note = "Funding Information: The authors acknowledge Amelie Vax and Sylvain Bourasseau for assistance with size-exclusion chromatography and Jean Michel Guigner for assistance with cryo-TEM analyses. CG received support from a Marie-Curie fellowship from the European Union under the Program H2020, Grant 749973 SENSHOR. PSA received support from CONACYT (scholarship holder No. 548662). This work benefited from the use of the SasView application, originally developed under NSF Award DMR-0520547. SasView also contains code developed with funding from the EU Horizon 2020 program under the SINE2020 project Grant No. 654000. This work was supported by the French national agency for research (ANR): Grant No. ANR-20-CE06-0020-01. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

year = "2021",

month = nov,

day = "21",

doi = "10.1039/d1py00995h",

language = "English",

volume = "12",

pages = "6242--6251",

journal = "Polymer Chemistry",

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Aqueous ROPISA of α-amino acid : N -carboxyanhydrides: Polypeptide block secondary structure controls nanoparticle shape anisotropy. / Grazon, Chloé; Salas-Ambrosio, Pedro; Antoine, Ségolène; Ibarboure, Emmanuel; Sandre, Olivier; Clulow, Andrew J.; Boyd, Ben J.; Grinstaff, Mark W.; Lecommandoux, Sébastien; Bonduelle, Colin.

In: Polymer Chemistry, Vol. 12, No. 43, 21.11.2021, p. 6242-6251.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Aqueous ROPISA of α-amino acid

T2 - N -carboxyanhydrides: Polypeptide block secondary structure controls nanoparticle shape anisotropy

AU - Grazon, Chloé

AU - Salas-Ambrosio, Pedro

AU - Antoine, Ségolène

AU - Ibarboure, Emmanuel

AU - Sandre, Olivier

AU - Clulow, Andrew J.

AU - Boyd, Ben J.

AU - Grinstaff, Mark W.

AU - Lecommandoux, Sébastien

AU - Bonduelle, Colin

N1 - Funding Information: The authors acknowledge Amelie Vax and Sylvain Bourasseau for assistance with size-exclusion chromatography and Jean Michel Guigner for assistance with cryo-TEM analyses. CG received support from a Marie-Curie fellowship from the European Union under the Program H2020, Grant 749973 SENSHOR. PSA received support from CONACYT (scholarship holder No. 548662). This work benefited from the use of the SasView application, originally developed under NSF Award DMR-0520547. SasView also contains code developed with funding from the EU Horizon 2020 program under the SINE2020 project Grant No. 654000. This work was supported by the French national agency for research (ANR): Grant No. ANR-20-CE06-0020-01. Publisher Copyright: © The Royal Society of Chemistry.

PY - 2021/11/21

Y1 - 2021/11/21

N2 - Polymerization-induced self-assembly (PISA) is an efficient one-step process to obtain nanomaterials. In this work, aqueous ring-opening polymerization induced self-assembly (ROPISA) of α-amino acid N-carboxyanhydride (NCA) affords controllable well-defined nanoassemblies. ROPISA with the PEG5 kDa-NH2 macroinitiator and either the benzyl-l-glutamate NCA (BLGNCA) or l-leucine NCA (LeuNCA) monomer yields amphiphilic block copolymers, with different polypeptide molar masses, which spontaneously form nanostructures. In contrast to the previous PISA process where the hydrophobic to hydrophilic ratio was the main parameter defining nanomaterial morphology, the secondary structure of the polypeptides is the main driving force to stabilize the anisotropic rod-like nanostructures with this ROPISA process. This journal is

AB - Polymerization-induced self-assembly (PISA) is an efficient one-step process to obtain nanomaterials. In this work, aqueous ring-opening polymerization induced self-assembly (ROPISA) of α-amino acid N-carboxyanhydride (NCA) affords controllable well-defined nanoassemblies. ROPISA with the PEG5 kDa-NH2 macroinitiator and either the benzyl-l-glutamate NCA (BLGNCA) or l-leucine NCA (LeuNCA) monomer yields amphiphilic block copolymers, with different polypeptide molar masses, which spontaneously form nanostructures. In contrast to the previous PISA process where the hydrophobic to hydrophilic ratio was the main parameter defining nanomaterial morphology, the secondary structure of the polypeptides is the main driving force to stabilize the anisotropic rod-like nanostructures with this ROPISA process. This journal is

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U2 - 10.1039/d1py00995h

DO - 10.1039/d1py00995h

M3 - Article

AN - SCOPUS:85119087682

VL - 12

SP - 6242

EP - 6251

JO - Polymer Chemistry

JF - Polymer Chemistry

SN - 1759-9954

IS - 43

ER -

Aqueous ROPISA of α-amino acid: N -carboxyanhydrides: Polypeptide block secondary structure controls nanoparticle shape anisotropy

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Milk Mimickry - Self-assembly in Complex Lipid Systems During Digestion

ARC Centre of Excellence in Convergent Bio-Nano Science and Technology

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Aqueous ROPISA of α-amino acid: N -carboxyanhydrides: Polypeptide block secondary structure controls nanoparticle shape anisotropy

Abstract

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Milk Mimickry - Self-assembly in Complex Lipid Systems During Digestion

ARC Centre of Excellence in Convergent Bio-Nano Science and Technology

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