Applications of Optically Active Aryl Cyanohydrins in the Synthesis of α-Hydroxy Aldehydes, α-Hydroxy Ketones and β-Hydroxy Amines

W. Roy Jackson, Howard A. Jacobs, Gamini S. Jayatilake, Barry R. Matthews, Keith G. Watson

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102 Citations (Scopus)


Cyanohydrins, prepared in high optical purity from aryl aldehydes, have been converted into α-hydroxy aldehydes, α-hydroxy ketones and β-hydroxy amines without any racemization and frequently with good stereoselectivity for the erythro-diastereoisorner (>90%) at the newly introduced stereogenic centre.

Original languageEnglish
Pages (from-to)2045-2062
Number of pages18
JournalAustralian Journal of Chemistry
Issue number12
Publication statusPublished - 1 Jan 1990

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