Applications of Optically Active Aryl Cyanohydrins in the Synthesis of α-Hydroxy Aldehydes, α-Hydroxy Ketones and β-Hydroxy Amines

W. Roy Jackson; Howard A. Jacobs; Gamini S. Jayatilake; Barry R. Matthews; Keith G. Watson

doi:10.1071/CH9902045

Applications of Optically Active Aryl Cyanohydrins in the Synthesis of α-Hydroxy Aldehydes, α-Hydroxy Ketones and β-Hydroxy Amines

W. Roy Jackson, Howard A. Jacobs, Gamini S. Jayatilake, Barry R. Matthews, Keith G. Watson

School of Chemistry

Research output: Contribution to journal › Article › Research › peer-review

102 Citations (Scopus)

Abstract

Cyanohydrins, prepared in high optical purity from aryl aldehydes, have been converted into α-hydroxy aldehydes, α-hydroxy ketones and β-hydroxy amines without any racemization and frequently with good stereoselectivity for the erythro-diastereoisorner (>90%) at the newly introduced stereogenic centre.

Original language	English
Pages (from-to)	2045-2062
Number of pages	18
Journal	Australian Journal of Chemistry
Volume	43
Issue number	12
DOIs	https://doi.org/10.1071/CH9902045
Publication status	Published - 1 Jan 1990

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abstract = "Cyanohydrins, prepared in high optical purity from aryl aldehydes, have been converted into α-hydroxy aldehydes, α-hydroxy ketones and β-hydroxy amines without any racemization and frequently with good stereoselectivity for the erythro-diastereoisorner (>90%) at the newly introduced stereogenic centre.",

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AU - Watson, Keith G.

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AB - Cyanohydrins, prepared in high optical purity from aryl aldehydes, have been converted into α-hydroxy aldehydes, α-hydroxy ketones and β-hydroxy amines without any racemization and frequently with good stereoselectivity for the erythro-diastereoisorner (>90%) at the newly introduced stereogenic centre.

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Applications of Optically Active Aryl Cyanohydrins in the Synthesis of α-Hydroxy Aldehydes, α-Hydroxy Ketones and β-Hydroxy Amines

Abstract

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