Applications of molecular replacement to G protein-coupled receptors

Andrew C Kruse, Aashish Manglik, Brian K. Kobilka, William I. Weis

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Abstract

G protein-coupled receptors (GPCRs) are a large class of integral membrane proteins involved in regulating virtually every aspect of human physiology. Despite their profound importance in human health and disease, structural information regarding GPCRs has been extremely limited until recently. With the advent of a variety of new biochemical and crystallographic techniques, the structural biology of GPCRs has advanced rapidly, offering key molecular insights into GPCR activation and signal transduction. To date, almost all GPCR structures have been solved using molecular-replacement techniques. Here, the unique aspects of molecular replacement as applied to individual GPCRs and to signaling complexes of these important proteins are discussed.

Original languageEnglish
Pages (from-to)2287-2292
Number of pages6
JournalActa Crystallographica Section D: Biological Crystallography
Volume69
Issue number11
DOIs
Publication statusPublished - Nov 2013
Externally publishedYes

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