Applications of fourier-transform infrared imaging in cancer research

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Abstract

False color images of cervical tissue sections, malignant glioma rat brain sections and melanoma sections have been constructed from FTIR hyperspectral data. The images are directly compared with stained sections and shown to be useful in distinguishing cervical pathology, malignant glioma and class I human lymphocyte antigen (HLA) expression in melanoma. Infrared spectra extracted from the images are shown to be useful for determining the macromolecular changes that accompany disease. Techniques for building three dimensional images to determine the extent of tissue change are described.

Original languageEnglish
Title of host publicationNew Approaches in Biomedical Spectroscopy
EditorsKatrin Kneipp, Harald Kneipp, Ricardo Aroca, Edeline Wentrup-Byrne
Pages14-29
Number of pages16
Publication statusPublished - 10 Dec 2007

Publication series

NameACS Symposium Series
Volume963
ISSN (Print)0097-6156

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