Application of proteomic tools in modern nanotechnological approaches towards effective management of neurodegenerative disorders

Ashraf Ali, Ishfaq Ahmed Sheikh, Zeenat Mirza, Siew Hua Gan, Mohammad Amjad Kamal, Adel M. Abuzenadah, Ghazi A. Damanhouri, Ghulam Md Ashraf

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Abstract

Neurodegeneration is the progressive loss of structure or function of neurons leading to neuronal death, usually associated with ageing. Some of the common neurodegenerative disorders include Alzheimer's disease, Parkinson's disease, Creutzfeldt-Jakob disease, and Huntington's disease. Due to recent advancements in highthroughput technologies in various disciplines such as genomics, epigenomics, metabolomics and proteomics, there has been a great demand for detection of specific macromolecules such as hormones, drug residues, miRNA, DNA, antibodies, peptides, proteins, pathogens and xenobiotics at nano-level concentrations for in-depth understanding of disease mechanisms as well as for the development of new therapeutic strategies. The present review focuses on the management of agerelated neurodegenerative disorders using proteomics and nanotechnological approaches. In addition, this review also highlights the metabolism and disposition of nano-drugs and nano-enabled drug delivery in neurodegenerative disorders.

Original languageEnglish
Pages (from-to)376-388
Number of pages13
JournalCurrent Drug Metabolism
Volume16
Issue number5
DOIs
Publication statusPublished - 1 Jun 2015
Externally publishedYes

Keywords

  • Disposition
  • Nano-applications
  • Nano-drugs
  • Nano-techniques
  • Nanotechnology
  • Neurological disorders
  • Proteomics

Cite this