Application of C18-Modified Mseoporous SBA-15 as the Substrate for High Performance Liquid Chromatography

Feng Gao, Jian Wei Zhao, Song Zhang, Feng Zhou, Wan Jin, Xiang Min Zhang, Peng Yuan Yang, Dong Yuan Zhao

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C18 functionalized mesoporous silica SBA-15 with a high surface area was applied in high performance liquid chromatography (HPLC) to separate small biomolecules: cysteine, glutathione, dopamine and 6-thiopurine. Compared to commercial available C18 column, C18-SBA-15 has a much higher surface area, which enhances the capillary HPLC resolution by increasing molecular capacity factors. The uniform distributed mesopores in SBA-15 result in HPLC peaks narrower than that of commercial column. Mesoporous SBA-15 can be used as an excellent HPLC stationary phase for special applications for its low cost, easy synthesis and various group-modifications.

Original languageEnglish
Number of pages1
JournalChemical Journal of Chinese Universities
Issue number8
Publication statusPublished - 1 Aug 2002
Externally publishedYes


  • HPLC
  • Mercapto compound
  • Mesoporous silica
  • SBA-15

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