Abstract
C18 functionalized mesoporous silica SBA-15 with a high surface area was applied in high performance liquid chromatography (HPLC) to separate small biomolecules: cysteine, glutathione, dopamine and 6-thiopurine. Compared to commercial available C18 column, C18-SBA-15 has a much higher surface area, which enhances the capillary HPLC resolution by increasing molecular capacity factors. The uniform distributed mesopores in SBA-15 result in HPLC peaks narrower than that of commercial column. Mesoporous SBA-15 can be used as an excellent HPLC stationary phase for special applications for its low cost, easy synthesis and various group-modifications.
Original language | English |
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Number of pages | 1 |
Journal | Chemical Journal of Chinese Universities |
Volume | 23 |
Issue number | 8 |
Publication status | Published - 1 Aug 2002 |
Externally published | Yes |
Keywords
- HPLC
- Mercapto compound
- Mesoporous silica
- SBA-15