Application of advanced gene set tests in breast cancer research

Di Wu, Die Wang

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Breast cancer is a heterogeneous disease with several molecular subtypesi?ZIt is important but challenging to find thea??cells of origina??from normal mammary gland for the different subtypesi?Z Gene set tests are used in microarray data analysis following individual gene testsi?Z The traditional way to test a gene set uses Fishera??s Exact Testi?Z The recent general gene set testsi??including competitive tests and self i?? contained testsi??take accounts of the statistics of individual genes in the seti?Z A number of gene set tests have been proposedi?Z But most suffer from one of two serious limitationsi?Z Bioinformaticians in the University of Melbourne developed the new methodsi??ii?Z ei?Z Camera and ROASTi??to analyze the similarities between human breast cancer subtypes and normal human mammary gland cell typesi?Z Based on the gene expression profilesi??it was found that the normal luminal progenitor cells are likely to be thea??cells of origina??of the basal i?? like breast cancer subtypei?Z This was one of the most important biomedical research results of the yeari?Z
Original languageEnglish
Pages (from-to)92 - 95
Number of pages4
JournalShengwu Xinxixue
Issue number2
Publication statusPublished - 2012

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