Apolipoprotein e gene associations in age-related macular degeneration

Madeleine Adams, Julie Anne Simpson, Andrea J Richardson, Dallas R English, Khin Zaw Aung, Galina A Makeyeva, Robyn Heather Guymer, Graham G Giles, John L Hopper, Liubov Robman, Paul N Baird

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The apolipoprotein E gene (APOE) has been found to be associated with age-related macular degeneration (AMD). Reported associations have been questioned, as they are opposite those for Alzheimer s disease and cardiovascular disease. The authors examined associations between APOE genotype and AMD using a case-control study (2,287 cases and 2,287 controls individually matched on age, sex, and country of origin) nested within Melbourne Collaborative Cohort Study participants aged 48-86 years at AMD detection. The odds ratio for early AMD among participants with e2-containing genotypes (e2e2/e2e3/e2e4) was 1.32 (95 confidence interval (CI): 1.11, 1.58; P = 0.002) versus persons with genotype e3e3. Associations with early AMD varied by smoking status; e2-containing genotypes were positively associated with early AMD for never and previous smokers (never smokers: odds ratio (OR) = 1.40, 95 CI: 1.12, 1.76 (P = 0.003); previous smokers: OR = 1.39, 95 CI: 1.00, 1.93 (P = 0.05)) but not for current smokers (OR = 0.66, 95 CI: 0.34, 1.30 (P = 0.2; interaction P = 0.05). The e4-containing genotype group (e3e4/e4e4) had an inverse association with early AMD among current smokers only (OR = 0.41, 95 CI: 0.22, 0.77 (P = 0.005)). These results highlight the importance of stratifying by smoking status in elderly populations. Smokers who survive to old age may be more likely to possess unknown genotypes which modify exposure-disease associations.
Original languageEnglish
Pages (from-to)511 - 518
Number of pages8
JournalAmerican Journal of Epidemiology
Issue number6
Publication statusPublished - 2012

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Adams, M., Simpson, J. A., Richardson, A. J., English, D. R., Aung, K. Z., Makeyeva, G. A., Guymer, R. H., Giles, G. G., Hopper, J. L., Robman, L., & Baird, P. N. (2012). Apolipoprotein e gene associations in age-related macular degeneration. American Journal of Epidemiology, 175(6), 511 - 518. https://doi.org/10.1093/aje/kwr329