Apolipoprotein D Gene Polymorphism: A New Genetic Marker for Type 2 Diabetic Subjects in Nauru and South India

W. A. Baker, G. A. Hitman, K. Hawrami, M. I. McCarthy, A. Riikonen, E. Tuomilehto‐Wolf, A. Nissinen, J. Tuomilehto, V. Mohan, M. Viswanathan, C. Snehalatha, A. Ramachandran, G. K. Dowse, P. Zimmet, S. W. Serjeantsona

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Abstract

Type 2 diabetes is characterized by abnormalities in both glucose and lipoprotein metabolism and genes involved in lipid metabolism are legitimate candidates for involvement in Type 2 diabetes. We have previously reported an association in Nauruans between a Taq 1 polymorphism of the apolipoprotein D gene (apo D) and Type 2 diabetes. In this study these findings were investigated further in the Nauruan population as well as two other ethnic groups. In South Indian subjects, there was a significant difference in genotype distribution of apo D genotypes between diabetic subjects (n = 110) and controls (n = 88; p = 0.004) which was similar to that previously found in the Nauruan subjects. No such association was seen in elderly Finnish subjects (diabetic n = 69; impaired glucose tolerance n = 26 and normal glucose tolerance n = 31). Linkage between the apo D polymorphism and diabetes in 12 Nauruan families was only excluded under a highly penetrant dominant model and was unlikely under other single gene models. Since the β cell glucose transporter gene (Glut 2) is found in a similar chromosomal location to apo D, South Indian subjects (diabetic n = 95 and controls n = 56) were typed at this locus. No association between diabetes and the Glut 2 Taq I polymorphism was found in the South Indian subjects. Furthermore, there was no evidence of linkage disequilibrium between the apo D and Glut 2 genes. In conclusion, apo D might act as a modifying gene for Type 2 diabetes in some ethnic groups. 1994 Diabetes UK

Original languageEnglish
Pages (from-to)947-952
Number of pages6
JournalDiabetic Medicine
Volume11
Issue number10
DOIs
Publication statusPublished - Dec 1994
Externally publishedYes

Keywords

  • Apolipoprotein D gene
  • Association
  • Genetics
  • Glucose transporters
  • Type 2 diabetes

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