Apnoea of prematurity and arousal from sleep

Rosemary S.C. Horne, Sarah Andrew, Kristy Mitchell, David J. Sly, Susan M. Cranage, Bonnie Chau, T. Michael Adamson

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Abstract

The incidence of sudden infant death syndrome (SIDS) has been found to be consistently higher in preterm and low birth weight infants than in infants born at term and this increase is inversely related to gestational age. The incidence and severity of apnoea of prematurity, are also inversely related to gestational age. The aim of this study was to investigate whether a neonatal history of apnoea/bradycardia affected the maturation of arousal responses. Twenty-five premature infants were studied. A perinatal risk score was determined for each infant and infants were divided into those with a neonatal history of apnoea/bradycardia (n=16) and those without (n=9). All infants were studied using daytime polysomnography on three occasions: (a) a preterm study around 36 weeks gestation, (b) within 3 weeks of term, and (c) 2-3 months post-term. Multiple measurements of arousal threshold (cmH2O) in response to air-jet stimulation applied alternately to the nares were made in both active sleep (AS) and quiet sleep (QS). Arousal thresholds were elevated in apnoeic infants compared to control infants in both AS (P<0.05) and QS (P<0.001) at the term study and in QS at 2-3 months post-term (P<0.01). In addition, arousal thresholds were positively correlated with perinatal risk score in both sleep states, in all studies, with the exception of AS at 2-3 months when all infants were readily arouseable. We conclude that a history of prematurity with neonatal apnoea has a persisting effect on decreasing arousabilty from sleep and these infants may be at increased risk for SIDS.

Original languageEnglish
Pages (from-to)119-133
Number of pages15
JournalEarly Human Development
Volume61
Issue number2
DOIs
Publication statusPublished - 24 Feb 2001

Keywords

  • Apnoea of prematurity
  • Arousal
  • Premature infants
  • SIDS
  • Sleep

Cite this

Horne, R. S. C., Andrew, S., Mitchell, K., Sly, D. J., Cranage, S. M., Chau, B., & Adamson, T. M. (2001). Apnoea of prematurity and arousal from sleep. Early Human Development, 61(2), 119-133. https://doi.org/10.1016/S0378-3782(00)00129-8
Horne, Rosemary S.C. ; Andrew, Sarah ; Mitchell, Kristy ; Sly, David J. ; Cranage, Susan M. ; Chau, Bonnie ; Adamson, T. Michael. / Apnoea of prematurity and arousal from sleep. In: Early Human Development. 2001 ; Vol. 61, No. 2. pp. 119-133.
@article{ac95c8c40ed748ad9ddcbebda53e2ca0,
title = "Apnoea of prematurity and arousal from sleep",
abstract = "The incidence of sudden infant death syndrome (SIDS) has been found to be consistently higher in preterm and low birth weight infants than in infants born at term and this increase is inversely related to gestational age. The incidence and severity of apnoea of prematurity, are also inversely related to gestational age. The aim of this study was to investigate whether a neonatal history of apnoea/bradycardia affected the maturation of arousal responses. Twenty-five premature infants were studied. A perinatal risk score was determined for each infant and infants were divided into those with a neonatal history of apnoea/bradycardia (n=16) and those without (n=9). All infants were studied using daytime polysomnography on three occasions: (a) a preterm study around 36 weeks gestation, (b) within 3 weeks of term, and (c) 2-3 months post-term. Multiple measurements of arousal threshold (cmH2O) in response to air-jet stimulation applied alternately to the nares were made in both active sleep (AS) and quiet sleep (QS). Arousal thresholds were elevated in apnoeic infants compared to control infants in both AS (P<0.05) and QS (P<0.001) at the term study and in QS at 2-3 months post-term (P<0.01). In addition, arousal thresholds were positively correlated with perinatal risk score in both sleep states, in all studies, with the exception of AS at 2-3 months when all infants were readily arouseable. We conclude that a history of prematurity with neonatal apnoea has a persisting effect on decreasing arousabilty from sleep and these infants may be at increased risk for SIDS.",
keywords = "Apnoea of prematurity, Arousal, Premature infants, SIDS, Sleep",
author = "Horne, {Rosemary S.C.} and Sarah Andrew and Kristy Mitchell and Sly, {David J.} and Cranage, {Susan M.} and Bonnie Chau and Adamson, {T. Michael}",
year = "2001",
month = "2",
day = "24",
doi = "10.1016/S0378-3782(00)00129-8",
language = "English",
volume = "61",
pages = "119--133",
journal = "Early Human Development",
issn = "0378-3782",
publisher = "Elsevier",
number = "2",

}

Horne, RSC, Andrew, S, Mitchell, K, Sly, DJ, Cranage, SM, Chau, B & Adamson, TM 2001, 'Apnoea of prematurity and arousal from sleep', Early Human Development, vol. 61, no. 2, pp. 119-133. https://doi.org/10.1016/S0378-3782(00)00129-8

Apnoea of prematurity and arousal from sleep. / Horne, Rosemary S.C.; Andrew, Sarah; Mitchell, Kristy; Sly, David J.; Cranage, Susan M.; Chau, Bonnie; Adamson, T. Michael.

In: Early Human Development, Vol. 61, No. 2, 24.02.2001, p. 119-133.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Apnoea of prematurity and arousal from sleep

AU - Horne, Rosemary S.C.

AU - Andrew, Sarah

AU - Mitchell, Kristy

AU - Sly, David J.

AU - Cranage, Susan M.

AU - Chau, Bonnie

AU - Adamson, T. Michael

PY - 2001/2/24

Y1 - 2001/2/24

N2 - The incidence of sudden infant death syndrome (SIDS) has been found to be consistently higher in preterm and low birth weight infants than in infants born at term and this increase is inversely related to gestational age. The incidence and severity of apnoea of prematurity, are also inversely related to gestational age. The aim of this study was to investigate whether a neonatal history of apnoea/bradycardia affected the maturation of arousal responses. Twenty-five premature infants were studied. A perinatal risk score was determined for each infant and infants were divided into those with a neonatal history of apnoea/bradycardia (n=16) and those without (n=9). All infants were studied using daytime polysomnography on three occasions: (a) a preterm study around 36 weeks gestation, (b) within 3 weeks of term, and (c) 2-3 months post-term. Multiple measurements of arousal threshold (cmH2O) in response to air-jet stimulation applied alternately to the nares were made in both active sleep (AS) and quiet sleep (QS). Arousal thresholds were elevated in apnoeic infants compared to control infants in both AS (P<0.05) and QS (P<0.001) at the term study and in QS at 2-3 months post-term (P<0.01). In addition, arousal thresholds were positively correlated with perinatal risk score in both sleep states, in all studies, with the exception of AS at 2-3 months when all infants were readily arouseable. We conclude that a history of prematurity with neonatal apnoea has a persisting effect on decreasing arousabilty from sleep and these infants may be at increased risk for SIDS.

AB - The incidence of sudden infant death syndrome (SIDS) has been found to be consistently higher in preterm and low birth weight infants than in infants born at term and this increase is inversely related to gestational age. The incidence and severity of apnoea of prematurity, are also inversely related to gestational age. The aim of this study was to investigate whether a neonatal history of apnoea/bradycardia affected the maturation of arousal responses. Twenty-five premature infants were studied. A perinatal risk score was determined for each infant and infants were divided into those with a neonatal history of apnoea/bradycardia (n=16) and those without (n=9). All infants were studied using daytime polysomnography on three occasions: (a) a preterm study around 36 weeks gestation, (b) within 3 weeks of term, and (c) 2-3 months post-term. Multiple measurements of arousal threshold (cmH2O) in response to air-jet stimulation applied alternately to the nares were made in both active sleep (AS) and quiet sleep (QS). Arousal thresholds were elevated in apnoeic infants compared to control infants in both AS (P<0.05) and QS (P<0.001) at the term study and in QS at 2-3 months post-term (P<0.01). In addition, arousal thresholds were positively correlated with perinatal risk score in both sleep states, in all studies, with the exception of AS at 2-3 months when all infants were readily arouseable. We conclude that a history of prematurity with neonatal apnoea has a persisting effect on decreasing arousabilty from sleep and these infants may be at increased risk for SIDS.

KW - Apnoea of prematurity

KW - Arousal

KW - Premature infants

KW - SIDS

KW - Sleep

UR - http://www.scopus.com/inward/record.url?scp=0035129368&partnerID=8YFLogxK

U2 - 10.1016/S0378-3782(00)00129-8

DO - 10.1016/S0378-3782(00)00129-8

M3 - Article

VL - 61

SP - 119

EP - 133

JO - Early Human Development

JF - Early Human Development

SN - 0378-3782

IS - 2

ER -

Horne RSC, Andrew S, Mitchell K, Sly DJ, Cranage SM, Chau B et al. Apnoea of prematurity and arousal from sleep. Early Human Development. 2001 Feb 24;61(2):119-133. https://doi.org/10.1016/S0378-3782(00)00129-8