Abstract
Conocurvone, a novel natural product isolated from the endemic Australian shrub Conosperum sp. (Proteaceae), exhibits anti-HIV activity but is a highly lipophilic compound, which suggests that there may be problems with its aqueous solubility and bioavailability. A general and convenient synthesis of trimeric naphthoquinones using the condensation of 2-hydroxynaphthoquinones and 2,3-dihaloquinones is described. The application of this method to the synthesis of a series of simpler and less lipophilic trimeric naphthoquinone simple analogues of conocurvone is also reported together with their anti-HIV activity.
Original language | English |
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Pages (from-to) | 768 - 784 |
Number of pages | 17 |
Journal | Australian Journal of Chemistry |
Volume | 61 |
Issue number | 10 |
Publication status | Published - 2008 |