Abstract
The present study has been undertaken to investigate the antiulcer activity of Annona reticulate leaves extract in rats. In Ethanol and indomethacine induced ulcer model, Extract or reference or vehicle was administered to 24 hours fasted rats, after 30 min, 50% alcohol or indomethacine was administered. After 1 hour, rats were sacrificed and ulcer index and related parameters were determined. Annona reticulate (100 & 200 mg/kg doses) and Reference drug (3mg/kg) has shown significant decrease in ulcer index, acid volume and content and showed improvement in glutathione and pH when compared with vehicle control. Therefore, aqueous extract of leaves of Annona reticulate is a potent antiulcer agent.
| Original language | English |
|---|---|
| Pages (from-to) | 412-414 |
| Number of pages | 3 |
| Journal | International Journal of Pharmacy and Pharmaceutical Sciences |
| Volume | 4 |
| Issue number | 1 |
| Publication status | Published - 2012 |
| Externally published | Yes |
Keywords
- Antiulcer
- Ethanol
- Glutathione
- Indomethacine
- Ulcer index