Antiretroviral Treatment Interruption and Loss to Follow-Up in Two HIV Cohorts in Australia and Asia: Implications for 'Test and Treat' Prevention Strategy

Rebecca Guy, Handan Wand, Hamish McManus, Vonthanak Saphon, Ian John Woolley, Miwako Honda, Tim Read, Thira Sirisanthana, Julian Zhou

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Abstract

Abstract Both antiretroviral treatment interruption (TI) and cessation have been strongly discouraged since 2006. We describe the incidence, duration, and risk factors for TI and loss-to-follow-up (LTFU) rates across 13 countries. All 4689 adults (76 men) in two large HIV cohorts in Australia and Asia commencing combination antiretroviral therapy (ART) to March 2010 were included. TI was defined by ART cessation >30 days, then recommencement, and loss to follow-up (LTFU) by no visit since 31 March 2009 and no record of death. Survival analysis and Poisson regression methods were used. With median follow-up of 4.4 years [interquartile range (IQR):2.1-6.5], TI incidence was 6.7 per 100 person years (PY) (95 CI:6.1-7.3) pre-2006, falling to 2.0 (95 CI:1.7-2.2) from 2006 (p/=7 pills per day; and ART with food restrictions (fasting or with food). In conclusion, since 2006, 7.8 of patients had significant time off treatment, which has the potential to compromise any test and treat policy as during the interruption viral load will rebound and increase the risk of transmission.
Original languageEnglish
Pages (from-to)681 - 691
Number of pages11
JournalAIDS Patient Care and STDs
Volume27
Issue number12
DOIs
Publication statusPublished - 2013

Cite this

Guy, Rebecca ; Wand, Handan ; McManus, Hamish ; Saphon, Vonthanak ; Woolley, Ian John ; Honda, Miwako ; Read, Tim ; Sirisanthana, Thira ; Zhou, Julian. / Antiretroviral Treatment Interruption and Loss to Follow-Up in Two HIV Cohorts in Australia and Asia: Implications for 'Test and Treat' Prevention Strategy. In: AIDS Patient Care and STDs. 2013 ; Vol. 27, No. 12. pp. 681 - 691.
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abstract = "Abstract Both antiretroviral treatment interruption (TI) and cessation have been strongly discouraged since 2006. We describe the incidence, duration, and risk factors for TI and loss-to-follow-up (LTFU) rates across 13 countries. All 4689 adults (76 men) in two large HIV cohorts in Australia and Asia commencing combination antiretroviral therapy (ART) to March 2010 were included. TI was defined by ART cessation >30 days, then recommencement, and loss to follow-up (LTFU) by no visit since 31 March 2009 and no record of death. Survival analysis and Poisson regression methods were used. With median follow-up of 4.4 years [interquartile range (IQR):2.1-6.5], TI incidence was 6.7 per 100 person years (PY) (95 CI:6.1-7.3) pre-2006, falling to 2.0 (95 CI:1.7-2.2) from 2006 (p/=7 pills per day; and ART with food restrictions (fasting or with food). In conclusion, since 2006, 7.8 of patients had significant time off treatment, which has the potential to compromise any test and treat policy as during the interruption viral load will rebound and increase the risk of transmission.",
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Antiretroviral Treatment Interruption and Loss to Follow-Up in Two HIV Cohorts in Australia and Asia: Implications for 'Test and Treat' Prevention Strategy. / Guy, Rebecca; Wand, Handan; McManus, Hamish; Saphon, Vonthanak; Woolley, Ian John; Honda, Miwako; Read, Tim; Sirisanthana, Thira; Zhou, Julian.

In: AIDS Patient Care and STDs, Vol. 27, No. 12, 2013, p. 681 - 691.

Research output: Contribution to journalArticleResearchpeer-review

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