Antioxidant vitamins and adrenocorticotrophic hormone-induced hypertension in rats

Christopher G. Schyvens, Miles C. Andrews, Rachel Tam, Trevor A. Mori, Kevin D. Croft, Katja U.S. McKenzie, Judith A. Whitworth, Yi Zhang

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5 Citations (Scopus)


This study examined whether the anti-oxidants ascorbic acid, α- or γ-tocopherol, could modify adrenocorticotrophic hormone (ACTH)-hypertension in Sprague-Dawley rats, a model associated with increased oxidative stress. Systolic blood pressure (SBP) was measured by the tail-cuff method. After four days of ascorbic acid (AA) (200mg/kg/day drinking) or α-tocopherol (500 mg/kg/d i.p. or feed), rats were co-administered ACTH (0.2 mg/kg/day s.c.) or saline for 11 days (prevention studies). In reversal studies, ACTH/saline was administered for 15 days, and from day 9, α- or γ-tocopherol (20 mg/kg/day) was added. ACTH increased SBP compared to saline (p < 0.05). AA or α-tocopherol failed to prevent and α- or γ-tocopherol failed to reverse ACTH-induced hypertension. Thus, neither vitamin C (water soluble) nor E (lipid soluble) modified ACTH-induced hypertension in the rat.

Original languageEnglish
Pages (from-to)465-478
Number of pages14
JournalClinical and Experimental Hypertension
Issue number7
Publication statusPublished - 1 Sep 2007
Externally publishedYes


  • Ascorbic acid
  • Hypertension
  • Tocopherol

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