Antioxidant Therapy for Severe Cardiac Failure Induced by Iron Overload Secondary to Dyserythropoietic Anaemia

Juliana van der Merwe, Jee Yoong Leong, David Kaye, Stephen Opat, Peter J. Bergin, Andrew J. Taylor, Franklin Rosenfeldt

Research output: Contribution to journalArticleOtherpeer-review

2 Citations (Scopus)

Abstract

We present a case of a patient with longstanding transfusion-dependent congenital dyserythropoietic anaemia (CDA) who developed cardiomyopathy despite iron chelation therapy. She presented with severe heart failure that responded poorly to conventional therapy, recovering only when therapy was augmented with metabolic agents including antioxidants and with increased iron chelation. The present case gives support to the concept of treating oxidatively induced heart failure with metabolic and antioxidant therapy. This therapy may have wider application in refractory heart failure and in the prevention of cardiomyopathy in patients receiving regular red cell transfusions who are at risk of transfusional haemosiderosis.

Original languageEnglish
Pages (from-to)394-397
Number of pages4
JournalHeart Lung and Circulation
Volume16
Issue number5
DOIs
Publication statusPublished - 1 Oct 2007

Keywords

  • Cardiac metabolism
  • Coenzyme Q
  • Congenital dyserythropoietic anaemia
  • Heart failure

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