TY - JOUR
T1 - Antioxidant and antiglycemic potentials of a standardized extract of Syzygium malaccense
AU - Arumugam, Bavani
AU - Manaharan, Thamilvaani
AU - Chua, Kek Heng
AU - Kuppusamy, Umah Rani
AU - Palanisamy, Uma Devi
PY - 2014
Y1 - 2014
N2 - The present study was designed to identify the ability of the leaf extract from Syzygium malaccense (L.) Merr. L.M. Perry to scavenge DPPH, ABTS and NO radicals; to inhibit the carbohydrate-hydrolyzing enzymes a-glucosidase and a-amylase; and, eventually, to identify and quantify its bioactive compound(s). The S. malaccense leaf extract was a far better scavenger of DPPH and ABTS than of nitric oxide. It also inhibited a-glucosidase more significantly than the positive control, acarbose, but was a poor a-amylase inhibitor. Myricitrin was identified by using high-performance liquid chromatography (HPLC) and liquid chromatography-mass spectrometry (LCMS) techniques as the major bioactive compound present in the extract. The percent yield of myricetin derivatives in the extract was determined to be 3.3 ? 0.05 . The presence of the potent antioxidant and antihyperglycemic agent myricitrin in the S. malaccense leaf extract indicates the potential use of the extract in the management of diabetes mellitus and its related complications.
AB - The present study was designed to identify the ability of the leaf extract from Syzygium malaccense (L.) Merr. L.M. Perry to scavenge DPPH, ABTS and NO radicals; to inhibit the carbohydrate-hydrolyzing enzymes a-glucosidase and a-amylase; and, eventually, to identify and quantify its bioactive compound(s). The S. malaccense leaf extract was a far better scavenger of DPPH and ABTS than of nitric oxide. It also inhibited a-glucosidase more significantly than the positive control, acarbose, but was a poor a-amylase inhibitor. Myricitrin was identified by using high-performance liquid chromatography (HPLC) and liquid chromatography-mass spectrometry (LCMS) techniques as the major bioactive compound present in the extract. The percent yield of myricetin derivatives in the extract was determined to be 3.3 ? 0.05 . The presence of the potent antioxidant and antihyperglycemic agent myricitrin in the S. malaccense leaf extract indicates the potential use of the extract in the management of diabetes mellitus and its related complications.
UR - http://www.sciencedirect.com/science/article/pii/S0023643814003946
U2 - 10.1016/j.lwt.2014.06.041
DO - 10.1016/j.lwt.2014.06.041
M3 - Article
SN - 0023-6438
VL - 59
SP - 707
EP - 712
JO - LWT
JF - LWT
IS - 2, part 1
ER -