Antimicrobial allergy 'labels' drive inappropriate antimicrobial prescribing: Lessons for stewardship

J. A. Trubiano, C. Chen, A. C. Cheng, M. L. Grayson, M. A. Slavin, K. A. Thursky, National Antimicrobial Prescribing Survey (NAPS)

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Background: The presence of antimicrobial allergy designations ('labels') often substantially reduces prescribing options for affected patients, but the frequency, accuracy and impacts of such labels are unknown. Methods: The National Antimicrobial Prescribing Survey (NAPS) is an annual de-identified point prevalence audit of Australian inpatient antimicrobial prescribing using standardized definitions of guideline compliance, appropriateness and indications. Data were extracted for 2 years (2013-14) and compared for patients with an antimicrobial allergy label (AAL) and with no AAL (NAAL). Results: Among 21031 patients receiving antimicrobials (33421 prescriptions), an AALwas recorded in 18%, with inappropriate antimicrobial use significantly higher in the AAL group versus the NAAL group (OR 1.12, 95% CI 1.05-1.22, P<0.002). Patterns of antimicrobial use were significantly influenced by AAL, with lower b-lactam use (AAL versus NAAL; OR 0.47, 95% CI 0.43-0.50, P,0.001) and higher quinolone (OR 2.07, 95% CI 1.83- 2.34, P,0.0001), glycopeptide (OR 1.59, 95% CI 1.38-1.83, P,0.0001) and carbapenem (OR 1.74, 95% CI 1.43-2.13, P<0.0001) use. In particular, among immunocompromised patients, AAL was associated with increased rates of inappropriate antimicrobial use (OR 1.68, 95% CI 1.21-2.30, P=0.003), as well as increased use of quinolones (OR 1.88, 95% CI 1.16-3.03, P=0.02) and glycopeptides (OR 1.82, 95% CI 1.17-2.84, P=0.01). Conclusions: AALs are common and appear to be associated with higher rates of inappropriate prescribing and increased use of broad-spectrum antimicrobials. Improved accuracy in defining AALs is likely to be important for effective antimicrobial stewardship (AMS), with efforts to 'de-label' inappropriate AAL patients a worthwhile feature of future AMS initiatives.

Original languageEnglish
Pages (from-to)1715-1722
Number of pages8
JournalJournal of Antimicrobial Chemotherapy
Issue number6
Publication statusPublished - 13 Jun 2016


  • antibiotics
  • hypersensitivity
  • glycopeptides
  • immunocompromised host
  • lactams
  • antimicrobials
  • appropriateness
  • prescribing behavior
  • antimicrobial stewardship program

Cite this

Trubiano, J. A., Chen, C., Cheng, A. C., Grayson, M. L., Slavin, M. A., Thursky, K. A., & National Antimicrobial Prescribing Survey (NAPS) (2016). Antimicrobial allergy 'labels' drive inappropriate antimicrobial prescribing: Lessons for stewardship. Journal of Antimicrobial Chemotherapy, 71(6), 1715-1722.