Antimicrobial activity of ruthenium-based intercalators

Albert Bolhuis, Lorna Hand, Julia E. Marshall, Adair D. Richards, Alison Rodger, Janice Aldrich-Wright

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Abstract

Multidrug resistance of bacterial pathogens is a major problem and there is a clear need for the development of new types of antibiotics. Here we investigated the antimicrobial activity of ruthenium(II) based DNA-intercalating complexes. These complexes were found to have no activity in vitro against the Gram-negative bacterium Escherichia coli, but the complexes were clearly active against the Gram-positive bacteria Bacillus subtilis and Staphylococcus aureus. In vivo activity has also been demonstrated for one of the compounds using a simple infection model, the nematode Caenorhabditis elegans. Importantly, this also showed that the compound tested was not toxic to the nematodes.

Original languageEnglish
Pages (from-to)313-317
Number of pages5
JournalEuropean Journal of Pharmaceutical Sciences
Volume42
Issue number4
DOIs
Publication statusPublished - 18 Mar 2011
Externally publishedYes

Keywords

  • Antimicrobial agents
  • Caenorhabditis elegans
  • DNA intercalator
  • Methicillin-resistant Staphylococcus aureus
  • Ruthenium complexes

Cite this

Bolhuis, A., Hand, L., Marshall, J. E., Richards, A. D., Rodger, A., & Aldrich-Wright, J. (2011). Antimicrobial activity of ruthenium-based intercalators. European Journal of Pharmaceutical Sciences, 42(4), 313-317. https://doi.org/10.1016/j.ejps.2010.12.004