Antimalarial Pyrido[1,2-a]benzimidazoles

Albert Ndakala; Richard Gessner; Patricia Gitari; Natasha October; Karen White; Alan Hudson; Foluke Fakorede; David Shackleford; Marcel Kaiser; Clive Yates; Susan Charman; Kelly Chibale

doi:10.1021/jm200227r

Antimalarial Pyrido[1,2-a]benzimidazoles

Albert Ndakala, Richard Gessner, Patricia Gitari, Natasha October, Karen White, Alan Hudson, Foluke Fakorede, David Shackleford, Marcel Kaiser, Clive Yates, Susan Charman, Kelly Chibale

Research output: Contribution to journal › Article › Research › peer-review

88 Citations (Scopus)

Abstract

Malaria continues to take an enormous toll on human health, particularly in tropical regions. The drugs used to treat this disease are far from ideal, and many of these were introduced decades ago. The utility of these medicaments in resource-poor settings is limited by a number of factors, such as high cost, poor compliance, drug resistance, low efficacy, and poor safety.

Original language	English
Pages (from-to)	4581 - 4589
Number of pages	9
Journal	Journal of Medicinal Chemistry
Volume	54
DOIs	https://doi.org/10.1021/jm200227r
Publication status	Published - 2011

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10.1021/jm200227r

Cite this

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title = "Antimalarial Pyrido[1,2-a]benzimidazoles",

abstract = "Malaria continues to take an enormous toll on human health, particularly in tropical regions. The drugs used to treat this disease are far from ideal, and many of these were introduced decades ago. The utility of these medicaments in resource-poor settings is limited by a number of factors, such as high cost, poor compliance, drug resistance, low efficacy, and poor safety.",

author = "Albert Ndakala and Richard Gessner and Patricia Gitari and Natasha October and Karen White and Alan Hudson and Foluke Fakorede and David Shackleford and Marcel Kaiser and Clive Yates and Susan Charman and Kelly Chibale",

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volume = "54",

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journal = "Journal of Medicinal Chemistry",

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T1 - Antimalarial Pyrido[1,2-a]benzimidazoles

AU - Ndakala, Albert

AU - Gessner, Richard

AU - Gitari, Patricia

AU - October, Natasha

AU - White, Karen

AU - Hudson, Alan

AU - Fakorede, Foluke

AU - Shackleford, David

AU - Kaiser, Marcel

AU - Yates, Clive

AU - Charman, Susan

AU - Chibale, Kelly

PY - 2011

Y1 - 2011

N2 - Malaria continues to take an enormous toll on human health, particularly in tropical regions. The drugs used to treat this disease are far from ideal, and many of these were introduced decades ago. The utility of these medicaments in resource-poor settings is limited by a number of factors, such as high cost, poor compliance, drug resistance, low efficacy, and poor safety.

AB - Malaria continues to take an enormous toll on human health, particularly in tropical regions. The drugs used to treat this disease are far from ideal, and many of these were introduced decades ago. The utility of these medicaments in resource-poor settings is limited by a number of factors, such as high cost, poor compliance, drug resistance, low efficacy, and poor safety.

UR - http://pubs.acs.org/doi/full/10.1021/jm200227r

U2 - 10.1021/jm200227r

DO - 10.1021/jm200227r

M3 - Article

VL - 54

SP - 4581

EP - 4589

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

SN - 0022-2623

ER -

Antimalarial Pyrido[1,2-a]benzimidazoles

Abstract

UN SDGs

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