Antimalarial drug discovery: targeting protein kinases

Christian D Doerig, Laurent Meijer

Research output: Contribution to journalArticleResearchpeer-review

72 Citations (Scopus)

Abstract

Protein kinases (PKs) are prime targets for drug discovery in a variety of diseases, including cancer and neurodegenerative pathologies. The characterisation of the kinome of the human malaria parasite Plasmodium falciparum has revealed profound divergences, at several levels, between PKs of the parasite and those of its host. Here, the authors review the major issues and recent advances regarding the development of Plasmodium-selective PK inhibitors, with emphasis on target identification and validation, and on structure-based design. The authors also discuss the possibility of interfering with: i) Plasmodium PKs regulating transmission to the mosquito vector; and ii) host PKs that may be required for parasite survival.
Original languageEnglish
Pages (from-to)279 - 290
Number of pages12
JournalExpert Opinion on Therapeutic Targets
Volume11
Issue number3
DOIs
Publication statusPublished - 2007
Externally publishedYes

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