Antimalarial activity of natural and synthetic prodiginines

Kancharla Papireddy, Martin Smilkstein, Jane Xu Kelly, Amany Shweta, Shaimaa M. Salem, Mamoun Alhamadsheh, Stuart W. Haynes, Gregory L. Challis, Kevin A. Reynolds

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126 Citations (Scopus)


Prodiginines are a family of linear and cyclic oligopyrrole red-pigmented compounds. Herein we describe the in vitro antimalarial activity of four natural (IC 50 = 1.7-8.0 nM) and three sets of synthetic prodiginines against Plasmodium falciparum. Set 1 compounds replaced the terminal nonalkylated pyrrole ring of natural prodiginines and had diminished activity (IC 50 > 2920 nM). Set 2 and set 3 prodiginines were monosubstituted or disubstituted at either the 3 or 5 position of the right-hand terminal pyrrole, respectively. Potent in vitro activity (IC 50 = 0.9-16.0 nM) was observed using alkyl or aryl substituents. Metacycloprodiginine and more potent synthetic analogues were evaluated in a P. yoelii murine patent infection using oral administration. Each analogue reduced parasitemia by more than 90% after 25 (mg/kg)/day dosing and in some cases provided a cure. The most favorable profile was 92% parasite reduction at 5 (mg/kg)/day, and 100% reduction at 25 (mg/kg)/day without any evident weight loses or clinical overt toxicity.

Original languageEnglish
Pages (from-to)5296-5306
Number of pages11
JournalJournal of Medicinal Chemistry
Issue number15
Publication statusPublished - 11 Aug 2011
Externally publishedYes

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