Antigens with repeated amino acid sequences from the asexual blood stages of Plasmodium falciparum

R. F. Anders, R. L. Coppel, G. V. Brown, D. J. Kemp

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During the last four years recombinant DNA technology has allowed a large number of antigens of the asexual blood stages of P. falciparum to be characterized in considerable detail [see Demp et al., 1986, 1987, for reviews]. The availability of the individual antigens, or fragments of them, expressed in recombinant DNA hosts or generated using peptide synthesis, is allowing direct assessment of the vaccine efficacy of these antigens [Collins et al., 1986; Cheung, et al., 1986]. The rapid progress being made in the search for vaccines against malaria is reviewed in other chapters of this book and will not be discussed here in detail. Instead, we will discuss the unusual structures of many asexual blood stage antigens that have been deduced from the nucleotide sequences of the corresponding clones.

Original languageEnglish
Pages (from-to)148-172
Number of pages25
JournalProgress in Allergy
Publication statusPublished - 1 Jan 1988

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