Abstract
Understanding the initiation of cellular immune responses during blood-stage malaria infection is essential for the development of an effective vaccine that improves upon the naturally acquired immune response and induces rapid and long-lasting protection against disease. Recent studies have identified the dendritic cell (DC) subtypes responsible for priming Plasmodium-specific T cells that mediate protection and/or pathology during blood-stage infection. Significant progress has also been made towards understanding DC recognition of Plasmodium parasites through engagement of TLR signalling pathways, as well as the potential for non-TLR ligands to mediate Plasmodium-induced suppression of DC antigen presentation.
Original language | English |
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Pages (from-to) | 119-123 |
Number of pages | 5 |
Journal | Current Opinion in Immunology |
Volume | 23 |
Issue number | 1 |
DOIs | |
Publication status | Published - Feb 2011 |
Externally published | Yes |