Antifungal activity of fluconazole-loaded natural rubber latex against Candida albicans

Mônica Yonashiro Marcelino, Felipe Azevedo Borges, Ana Flávia Martins Costa, Junya De Lacorte Singulani, Nathan Vinícius Ribeiro, Caroline Barcelos Costa-Orlandi, Bruna Cambraia Garms, Maria José Soares Mendes-Giannini, Rondinelli Donizetti Herculano, Ana Marisa Fusco-Almeida

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24 Citations (Scopus)

Abstract

Aim: This work aimed to produce a membrane based on fluconazole-loaded natural rubber latex (NRL), and study their interaction, drug release and antifungal susceptibility against Candida albicans. Materials & methods: Fluconazole-loaded NRL membrane was obtained by casting method. Results: The Fourier Transform Infrared Spectroscopy showed no modifications either in NRL or fluconazole after the incorporation. Mechanical test presented low Young's modulus and high strain, indicating the membranes have sufficient elasticity for biomedical application. The bio-membrane was able to release the drug and inhibit the growth of C. albicans as demonstrated by disk diffusion and macrodilution assays. Conclusion: The biomembrane was able to release fluconazole and inhibit the growth of C. albicans, representing a promising biomaterial for skin application.

Original languageEnglish
Pages (from-to)359-367
Number of pages9
JournalFuture Microbiology
Volume13
Issue number3
DOIs
Publication statusPublished - Mar 2018
Externally publishedYes

Keywords

  • Candida albicans
  • fluconazole
  • natural rubber latex (NRL)

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