TY - JOUR
T1 - Antifungal activity of fluconazole-loaded natural rubber latex against Candida albicans
AU - Yonashiro Marcelino, Mônica
AU - Azevedo Borges, Felipe
AU - Martins Costa, Ana Flávia
AU - De Lacorte Singulani, Junya
AU - Ribeiro, Nathan Vinícius
AU - Barcelos Costa-Orlandi, Caroline
AU - Garms, Bruna Cambraia
AU - Soares Mendes-Giannini, Maria José
AU - Herculano, Rondinelli Donizetti
AU - Fusco-Almeida, Ana Marisa
N1 - Funding Information:
This work was supported by Programa de Apoio ao Desenvolvimento Científico da Faculdade de Ciências Farmacêuticas da UNESP – PADC;Coordenac¸ãodeAperfeic¸oamentodePessoaldeNívelSuperior–CAPES;Fundac¸ãodeAmparoàPesquisa–FAPESP(Process 2014/17526–8; Process 2011/17411-8). The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. No writing assistance was utilized in the production of this manuscript.
Publisher Copyright:
© 2018 2018 Future Medicine Ltd.
PY - 2018/3
Y1 - 2018/3
N2 - Aim: This work aimed to produce a membrane based on fluconazole-loaded natural rubber latex (NRL), and study their interaction, drug release and antifungal susceptibility against Candida albicans. Materials & methods: Fluconazole-loaded NRL membrane was obtained by casting method. Results: The Fourier Transform Infrared Spectroscopy showed no modifications either in NRL or fluconazole after the incorporation. Mechanical test presented low Young's modulus and high strain, indicating the membranes have sufficient elasticity for biomedical application. The bio-membrane was able to release the drug and inhibit the growth of C. albicans as demonstrated by disk diffusion and macrodilution assays. Conclusion: The biomembrane was able to release fluconazole and inhibit the growth of C. albicans, representing a promising biomaterial for skin application.
AB - Aim: This work aimed to produce a membrane based on fluconazole-loaded natural rubber latex (NRL), and study their interaction, drug release and antifungal susceptibility against Candida albicans. Materials & methods: Fluconazole-loaded NRL membrane was obtained by casting method. Results: The Fourier Transform Infrared Spectroscopy showed no modifications either in NRL or fluconazole after the incorporation. Mechanical test presented low Young's modulus and high strain, indicating the membranes have sufficient elasticity for biomedical application. The bio-membrane was able to release the drug and inhibit the growth of C. albicans as demonstrated by disk diffusion and macrodilution assays. Conclusion: The biomembrane was able to release fluconazole and inhibit the growth of C. albicans, representing a promising biomaterial for skin application.
KW - Candida albicans
KW - fluconazole
KW - natural rubber latex (NRL)
UR - http://www.scopus.com/inward/record.url?scp=85042859329&partnerID=8YFLogxK
U2 - 10.2217/fmb-2017-0154
DO - 10.2217/fmb-2017-0154
M3 - Article
C2 - 29464962
AN - SCOPUS:85042859329
VL - 13
SP - 359
EP - 367
JO - Future Microbiology
JF - Future Microbiology
SN - 1746-0913
IS - 3
ER -