Antifibrotic properties of relaxin: in vivo mechanism of action in experimental renal tubulointerstitial fibrosis

Tim Hewitson, Wen Ho, Chrishan Samuel

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47 Citations (Scopus)

Abstract

This study examined the efficacy and in vivo mechanism of action of the antifibrotic hormone, relaxin, in a mouse model of unilateral ureteric obstruction (UUO). Kidney fibrosis was assessed in recombinant human gene-2 relaxin-treated animals maintained for 3 and 9 d after UUO. Results were compared with untreated and unoperated animals (d 0). Total collagen, collagen subtypes (I, IV), TGF-beta2 production, mothers against decapentaplegic homolog 2 (Smad2) phosphorylation, myofibroblast differentiation, mitosis, and apoptosis were all progressively increased by UUO (all P
Original languageEnglish
Pages (from-to)4938 - 4948
Number of pages11
JournalEndocrinology
Volume151
Issue number10
DOIs
Publication statusPublished - 2010
Externally publishedYes

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