Antifibrotic properties of relaxin: in vivo mechanism of action in experimental renal tubulointerstitial fibrosis

Tim Hewitson, Wen Ho, Chrishan Samuel

Research output: Contribution to journalArticleResearchpeer-review

53 Citations (Scopus)


This study examined the efficacy and in vivo mechanism of action of the antifibrotic hormone, relaxin, in a mouse model of unilateral ureteric obstruction (UUO). Kidney fibrosis was assessed in recombinant human gene-2 relaxin-treated animals maintained for 3 and 9 d after UUO. Results were compared with untreated and unoperated animals (d 0). Total collagen, collagen subtypes (I, IV), TGF-beta2 production, mothers against decapentaplegic homolog 2 (Smad2) phosphorylation, myofibroblast differentiation, mitosis, and apoptosis were all progressively increased by UUO (all P
Original languageEnglish
Pages (from-to)4938 - 4948
Number of pages11
Issue number10
Publication statusPublished - 2010
Externally publishedYes

Cite this