Antidepressants in the treatment for chronic low back pain: questioning the validity of meta-analyses

Owen Douglas Williamson; Doron Sagman; Robert Bruins; Luc J Boulay; Alexander Schacht

doi:10.1111/papr.12119

Antidepressants in the treatment for chronic low back pain: questioning the validity of meta-analyses

Owen Douglas Williamson
, Doron Sagman
, Robert Bruins
, Luc J Boulay
, Alexander Schacht

Epidemiology and Preventive Medicine Alfred Hospital

Research output: Contribution to journal › Article › Research › peer-review

16 Citations (Scopus)

Abstract

Due to the diversity of previous studies and the pooling methods used, the conclusions regarding the analgesic effect of antidepressants in CLBP drawn from systematic reviews must be interpreted with caution. Appropriately designed and powered studies similar to recently published duloxetine studies are recommended to demonstrate the analgesic effect of antidepressants.

Original language	English
Pages (from-to)	E33 - E41
Number of pages	9
Journal	Pain Practice
Volume	14
Issue number	2
DOIs	https://doi.org/10.1111/papr.12119
Publication status	Published - 2014

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10.1111/papr.12119

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title = "Antidepressants in the treatment for chronic low back pain: questioning the validity of meta-analyses",

abstract = "Due to the diversity of previous studies and the pooling methods used, the conclusions regarding the analgesic effect of antidepressants in CLBP drawn from systematic reviews must be interpreted with caution. Appropriately designed and powered studies similar to recently published duloxetine studies are recommended to demonstrate the analgesic effect of antidepressants.",

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AB - Due to the diversity of previous studies and the pooling methods used, the conclusions regarding the analgesic effect of antidepressants in CLBP drawn from systematic reviews must be interpreted with caution. Appropriately designed and powered studies similar to recently published duloxetine studies are recommended to demonstrate the analgesic effect of antidepressants.

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U2 - 10.1111/papr.12119

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JO - Pain Practice

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Antidepressants in the treatment for chronic low back pain: questioning the validity of meta-analyses

Abstract

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