Anticonvulsant effects of clonidine mediated through central α2-adrenoceptors

Jenny Papanicolaou; Roger J. Summers; Frank J.E. Vajda; Williams J. Louis

doi:10.1016/0014-2999(82)90013-9

Anticonvulsant effects of clonidine mediated through central α₂-adrenoceptors

Jenny Papanicolaou, Roger J. Summers, Frank J.E. Vajda, Williams J. Louis

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Abstract

The effect of centrally (0.3-30 ng/kg) and peripherally (0.01 μg/kg-1.0 mg/kg) administered clonidine on PTZ-induced seizures was studied in rats. At low doses, dose-dependent decreases in the duration of seizures was observed but at higher doses the duration returned to control levels. Anticonvulsant activity was antagonized by yohimbine (100 μg/kg i.p.) indicating α₂-adrenoceptor involvement, whereas the second phase of the response was antagonized by prazosin (10 ng/kg i.c.v.) indicating that it involved α₁-adrenoceptors.

Original language	English
Pages (from-to)	163-166
Number of pages	4
Journal	European Journal of Pharmacology
Volume	77
Issue number	2-3
DOIs	https://doi.org/10.1016/0014-2999(82)90013-9
Publication status	Published - 22 Jan 1982

Keywords

Clonidine
Convulsions
Pentylenetetrazol
α-Adrenoceptors

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10.1016/0014-2999(82)90013-9

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Cite this

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title = "Anticonvulsant effects of clonidine mediated through central α2-adrenoceptors",

abstract = "The effect of centrally (0.3-30 ng/kg) and peripherally (0.01 μg/kg-1.0 mg/kg) administered clonidine on PTZ-induced seizures was studied in rats. At low doses, dose-dependent decreases in the duration of seizures was observed but at higher doses the duration returned to control levels. Anticonvulsant activity was antagonized by yohimbine (100 μg/kg i.p.) indicating α2-adrenoceptor involvement, whereas the second phase of the response was antagonized by prazosin (10 ng/kg i.c.v.) indicating that it involved α1-adrenoceptors.",

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AU - Louis, Williams J.

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AB - The effect of centrally (0.3-30 ng/kg) and peripherally (0.01 μg/kg-1.0 mg/kg) administered clonidine on PTZ-induced seizures was studied in rats. At low doses, dose-dependent decreases in the duration of seizures was observed but at higher doses the duration returned to control levels. Anticonvulsant activity was antagonized by yohimbine (100 μg/kg i.p.) indicating α2-adrenoceptor involvement, whereas the second phase of the response was antagonized by prazosin (10 ng/kg i.c.v.) indicating that it involved α1-adrenoceptors.

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