Anticonvulsant effects of clonidine mediated through central α2-adrenoceptors

Jenny Papanicolaou, Roger J. Summers, Frank J.E. Vajda, Williams J. Louis

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Abstract

The effect of centrally (0.3-30 ng/kg) and peripherally (0.01 μg/kg-1.0 mg/kg) administered clonidine on PTZ-induced seizures was studied in rats. At low doses, dose-dependent decreases in the duration of seizures was observed but at higher doses the duration returned to control levels. Anticonvulsant activity was antagonized by yohimbine (100 μg/kg i.p.) indicating α2-adrenoceptor involvement, whereas the second phase of the response was antagonized by prazosin (10 ng/kg i.c.v.) indicating that it involved α1-adrenoceptors.

Original languageEnglish
Pages (from-to)163-166
Number of pages4
JournalEuropean Journal of Pharmacology
Volume77
Issue number2-3
DOIs
Publication statusPublished - 22 Jan 1982

Keywords

  • Clonidine
  • Convulsions
  • Pentylenetetrazol
  • α-Adrenoceptors

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