Anticancer activities of a benzimidazole compound through sirtuin inhibition in colorectal cancer

Yi Jer Tan, Yeuan Ting Lee, Keng Yoon Yeong, Sven H. Petersen, Koji Kono, Soo Choon Tan, Chern Ein Oon

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    7 Citations (Scopus)

    Abstract

    Aim: This study aims to investigate the mode of action of a novel sirtuin inhibitor (BZD9L1) and its associated molecular pathways in colorectal cancer (CRC) cells. Materials & methods: BZD9L1 was tested against metastatic CRC cell lines to evaluate cytotoxicity, cell cycle and apoptosis, senescence, apoptosis related genes and protein expressions, as well as effect against major cancer signaling pathways. Results & conclusion: BZD9L1 reduced the viability, cell migration and colony forming ability of both HCT 116 and HT-29 metastatic CRC cell lines through apoptosis. BZD9L1 regulated major cancer pathways differently in CRC with different mutation profiles. BZD9L1 exhibited anticancer activities as a cytotoxic drug in CRC and as a promising therapeutic strategy in CRC treatment.

    Original languageEnglish
    Pages (from-to)2039-2057
    Number of pages19
    JournalFuture Medicinal Chemistry
    Volume10
    Issue number17
    DOIs
    Publication statusPublished - Sep 2018

    Keywords

    • BZD9L1
    • colorectal cancer
    • sirtuin
    • targeted therapy

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