Anticancer activities of a benzimidazole compound through sirtuin inhibition in colorectal cancer

Yi Jer Tan, Yeuan Ting Lee, Keng Yoon Yeong, Sven H. Petersen, Koji Kono, Soo Choon Tan, Chern Ein Oon

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Abstract

Aim: This study aims to investigate the mode of action of a novel sirtuin inhibitor (BZD9L1) and its associated molecular pathways in colorectal cancer (CRC) cells. Materials & methods: BZD9L1 was tested against metastatic CRC cell lines to evaluate cytotoxicity, cell cycle and apoptosis, senescence, apoptosis related genes and protein expressions, as well as effect against major cancer signaling pathways. Results & conclusion: BZD9L1 reduced the viability, cell migration and colony forming ability of both HCT 116 and HT-29 metastatic CRC cell lines through apoptosis. BZD9L1 regulated major cancer pathways differently in CRC with different mutation profiles. BZD9L1 exhibited anticancer activities as a cytotoxic drug in CRC and as a promising therapeutic strategy in CRC treatment.

Original languageEnglish
Pages (from-to)2039-2057
Number of pages19
JournalFuture Medicinal Chemistry
Volume10
Issue number17
DOIs
Publication statusPublished - Sep 2018

Keywords

  • BZD9L1
  • colorectal cancer
  • sirtuin
  • targeted therapy

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