Antibody responses with Fc-mediated functions after vaccination of HIV-infected subjects with trivalent influenza vaccine

Anne B. Kristensen, William N. Lay, Fernanda Ana-Sosa-Batiz, Hillary A. Vanderven, Vijaya Madhavi, Karen L. Laurie, Louise Carolan, Bruce D. Wines, Mark Hogarth, Adam K. Wheatley, Stephen J. Kent

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34 Citations (Scopus)

Abstract

This study seeks to assess the ability of seasonal trivalent inactivated influenza vaccine (TIV) to induce nonneutralizing antibodies (Abs) with Fc-mediated functions in HIV-uninfected and HIV-infected subjects. Functional influenza-specific Ab responses were studied in 30 HIV-negative and 27 HIV-positive subjects immunized against seasonal influenza. All 57 subjects received the 2015 TIV. Fc-mediated antihemagglutinin (anti-HA) Ab activity was measured in plasma before and 4 weeks after vaccination using Fc-receptor-binding assays, NK cell activation assays, and phagocytosis assays. At baseline, the HIV-positive group had detectable but reduced functional Ab responses to both vaccine and nonvaccine influenza antigens. TIV enhanced Fc-mediated Ab responses in both HIV-positive and HIV-negative groups. A larger rise was generally observed in the HIV-positive group, such that there was no difference in functional Ab responses between the two groups after vaccination. The 2015 TIV enhanced functional influenza-specific Ab responses in both HIV-negative and HIV-positive subjects to a range of influenza HA proteins. The increase in functional Ab responses in the HIV-positive group supports recommendations to immunize this at-risk group.

Original languageEnglish
Pages (from-to)5724-5734
Number of pages11
JournalJournal of Virology
Volume90
Issue number12
DOIs
Publication statusPublished - 1 Jun 2016

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