Antibody-mediated rejection of the lung: A consensus report of the International Society for Heart and Lung Transplantation

Deborah J. Levine; Allan R. Glanville; Christina Aboyoun; John Belperio; Christian Benden; Gerald J. Berry; Ramsey Hachem; Don Hayes; Desley Neil; Nancy L. Reinsmoen; Laurie D. Snyder; Stuart Sweet; Dolly Tyan; Geert Verleden; Glen Westall; Roger D. Yusen; Martin Zamora; Adriana Zeevi

doi:10.1016/j.healun.2016.01.1223

Antibody-mediated rejection of the lung: A consensus report of the International Society for Heart and Lung Transplantation

Deborah J. Levine, Allan R. Glanville, Christina Aboyoun, John Belperio, Christian Benden, Gerald J. Berry, Ramsey Hachem, Don Hayes, Desley Neil, Nancy L. Reinsmoen, Laurie D. Snyder, Stuart Sweet, Dolly Tyan, Geert Verleden, Glen Westall, Roger D. Yusen, Martin Zamora, Adriana Zeevi

Research output: Contribution to journal › Article › Other › peer-review

346 Citations (Scopus)

Abstract

Antibody-mediated rejection (AMR) is a recognized cause of allograft dysfunction in lung transplant recipients. Unlike AMR in other solid-organ transplant recipients, there are no standardized diagnostic criteria or an agreed-upon definition. Hence, a working group was created by the International Society for Heart and Lung Transplantation with the aim of determining criteria for pulmonary AMR and establishing a definition. Diagnostic criteria and a working consensus definition were established. Key diagnostic criteria include the presence of antibodies directed toward donor human leukocyte antigens and characteristic lung histology with or without evidence of complement 4d within the graft. Exclusion of other causes of allograft dysfunction increases confidence in the diagnosis but is not essential. Pulmonary AMR may be clinical (allograft dysfunction which can be asymptomatic) or sub-clinical (normal allograft function). This consensus definition will have clinical, therapeutic and research implications.

Original language	English
Pages (from-to)	397-406
Number of pages	10
Journal	The Journal of Heart and Lung Transplantation
Volume	35
Issue number	4
DOIs	https://doi.org/10.1016/j.healun.2016.01.1223
Publication status	Published - Apr 2016
Externally published	Yes

Keywords

allograft dysfunction
HLA antibodies
lung transplantation
rejection

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Levine, D. J., Glanville, A. R., Aboyoun, C., Belperio, J., Benden, C., Berry, G. J., Hachem, R., Hayes, D., Neil, D., Reinsmoen, N. L., Snyder, L. D., Sweet, S., Tyan, D., Verleden, G., Westall, G., Yusen, R. D., Zamora, M., & Zeevi, A. (2016). Antibody-mediated rejection of the lung: A consensus report of the International Society for Heart and Lung Transplantation. The Journal of Heart and Lung Transplantation, 35(4), 397-406. https://doi.org/10.1016/j.healun.2016.01.1223

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title = "Antibody-mediated rejection of the lung: A consensus report of the International Society for Heart and Lung Transplantation",

abstract = "Antibody-mediated rejection (AMR) is a recognized cause of allograft dysfunction in lung transplant recipients. Unlike AMR in other solid-organ transplant recipients, there are no standardized diagnostic criteria or an agreed-upon definition. Hence, a working group was created by the International Society for Heart and Lung Transplantation with the aim of determining criteria for pulmonary AMR and establishing a definition. Diagnostic criteria and a working consensus definition were established. Key diagnostic criteria include the presence of antibodies directed toward donor human leukocyte antigens and characteristic lung histology with or without evidence of complement 4d within the graft. Exclusion of other causes of allograft dysfunction increases confidence in the diagnosis but is not essential. Pulmonary AMR may be clinical (allograft dysfunction which can be asymptomatic) or sub-clinical (normal allograft function). This consensus definition will have clinical, therapeutic and research implications.",

keywords = "allograft dysfunction, HLA antibodies, lung transplantation, rejection",

author = "Levine, {Deborah J.} and Glanville, {Allan R.} and Christina Aboyoun and John Belperio and Christian Benden and Berry, {Gerald J.} and Ramsey Hachem and Don Hayes and Desley Neil and Reinsmoen, {Nancy L.} and Snyder, {Laurie D.} and Stuart Sweet and Dolly Tyan and Geert Verleden and Glen Westall and Yusen, {Roger D.} and Martin Zamora and Adriana Zeevi",

year = "2016",

month = apr,

doi = "10.1016/j.healun.2016.01.1223",

language = "English",

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pages = "397--406",

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Levine, DJ, Glanville, AR, Aboyoun, C, Belperio, J, Benden, C, Berry, GJ, Hachem, R, Hayes, D, Neil, D, Reinsmoen, NL, Snyder, LD, Sweet, S, Tyan, D, Verleden, G, Westall, G, Yusen, RD, Zamora, M & Zeevi, A 2016, 'Antibody-mediated rejection of the lung: A consensus report of the International Society for Heart and Lung Transplantation', The Journal of Heart and Lung Transplantation, vol. 35, no. 4, pp. 397-406. https://doi.org/10.1016/j.healun.2016.01.1223

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T2 - A consensus report of the International Society for Heart and Lung Transplantation

AU - Levine, Deborah J.

AU - Glanville, Allan R.

AU - Aboyoun, Christina

AU - Belperio, John

AU - Benden, Christian

AU - Berry, Gerald J.

AU - Hachem, Ramsey

AU - Hayes, Don

AU - Neil, Desley

AU - Reinsmoen, Nancy L.

AU - Snyder, Laurie D.

AU - Sweet, Stuart

AU - Tyan, Dolly

AU - Verleden, Geert

AU - Westall, Glen

AU - Yusen, Roger D.

AU - Zamora, Martin

AU - Zeevi, Adriana

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AB - Antibody-mediated rejection (AMR) is a recognized cause of allograft dysfunction in lung transplant recipients. Unlike AMR in other solid-organ transplant recipients, there are no standardized diagnostic criteria or an agreed-upon definition. Hence, a working group was created by the International Society for Heart and Lung Transplantation with the aim of determining criteria for pulmonary AMR and establishing a definition. Diagnostic criteria and a working consensus definition were established. Key diagnostic criteria include the presence of antibodies directed toward donor human leukocyte antigens and characteristic lung histology with or without evidence of complement 4d within the graft. Exclusion of other causes of allograft dysfunction increases confidence in the diagnosis but is not essential. Pulmonary AMR may be clinical (allograft dysfunction which can be asymptomatic) or sub-clinical (normal allograft function). This consensus definition will have clinical, therapeutic and research implications.

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ER -

Antibody-mediated rejection of the lung: A consensus report of the International Society for Heart and Lung Transplantation

Abstract

Keywords

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