TY - JOUR
T1 - Antibody-dependent cellular cytotoxicity and influenza virus
AU - Vanderven, Hillary A.
AU - Jegaskanda, Sinthujan
AU - Wheatley, Adam K.
AU - Kent, Stephen J.
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Antibodies are a key defence against influenza infection and disease, but neutralizing antibodies are often strain-specific and of limited utility against divergent or pandemic viruses. There is now considerable evidence that influenza-specific antibodies with Fc-mediated effector functions, such as antibody-dependent cellular cytotoxicity (ADCC), can assist in the clearance of influenza infection in vitro and in animal models. Further, ADCC-mediating antibodies that recognize a broad array of influenza strains are common in humans, likely as a result of being regularly exposed to influenza infections. The concept that influenza-specific ADCC can assist in the partial control of influenza infections in humans is gaining momentum. This review examines the utility of influenza-specific ADCC antibodies.
AB - Antibodies are a key defence against influenza infection and disease, but neutralizing antibodies are often strain-specific and of limited utility against divergent or pandemic viruses. There is now considerable evidence that influenza-specific antibodies with Fc-mediated effector functions, such as antibody-dependent cellular cytotoxicity (ADCC), can assist in the clearance of influenza infection in vitro and in animal models. Further, ADCC-mediating antibodies that recognize a broad array of influenza strains are common in humans, likely as a result of being regularly exposed to influenza infections. The concept that influenza-specific ADCC can assist in the partial control of influenza infections in humans is gaining momentum. This review examines the utility of influenza-specific ADCC antibodies.
UR - http://www.scopus.com/inward/record.url?scp=85011887531&partnerID=8YFLogxK
U2 - 10.1016/j.coviro.2016.12.002
DO - 10.1016/j.coviro.2016.12.002
M3 - Review Article
AN - SCOPUS:85011887531
VL - 22
SP - 89
EP - 96
JO - Current Opinion in Virology
JF - Current Opinion in Virology
SN - 1879-6257
ER -