Antibody blockade of c-fms suppresses the progression of inflammation and injury in early diabetic nephropathy in obese db/db mice

Andy Kim Ho Lim; Frank Ma; David Nicolic-Paterson; Merlin Thomas; Lynette A Hurst; Gregory H Tesch

Antibody blockade of c-fms suppresses the progression of inflammation and injury in early diabetic nephropathy in obese db/db mice

Andy Kim Ho Lim, Frank Ma, David Nicolic-Paterson, Merlin Thomas, Lynette A Hurst, Gregory H Tesch

Medicine Monash Health

Research output: Contribution to journal › Article › Research › peer-review

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Abstract

Antibody blockade of c-fms suppresses the progression of inflammation and injury in early diabetic nephropathy in obese db/db mice. AIMS/HYPOTHESIS: Macrophage-mediated renal injury plays an important role in the development of diabetic nephropathy. Colony-stimulating factor (CSF)-1 is a cytokine that is produced in diabetic kidneys and promotes macrophage accumulation, activation and survival. CSF-1 acts exclusively through the c-fms receptor, which is only expressed on cells of the monocyte-macrophage lineage. Therefore, we used c-fms blockade as a strategy to selectively target macrophage-mediated injury during the progression of diabetic nephropathy.

Original language	English
Pages (from-to)	1669 - 1679
Number of pages	11
Journal	Diabetologia
Volume	52
Issue number	8
Publication status	Published - 2009

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title = "Antibody blockade of c-fms suppresses the progression of inflammation and injury in early diabetic nephropathy in obese db/db mice",

abstract = "Antibody blockade of c-fms suppresses the progression of inflammation and injury in early diabetic nephropathy in obese db/db mice. AIMS/HYPOTHESIS: Macrophage-mediated renal injury plays an important role in the development of diabetic nephropathy. Colony-stimulating factor (CSF)-1 is a cytokine that is produced in diabetic kidneys and promotes macrophage accumulation, activation and survival. CSF-1 acts exclusively through the c-fms receptor, which is only expressed on cells of the monocyte-macrophage lineage. Therefore, we used c-fms blockade as a strategy to selectively target macrophage-mediated injury during the progression of diabetic nephropathy.",

author = "Lim, {Andy Kim Ho} and Frank Ma and David Nicolic-Paterson and Merlin Thomas and Hurst, {Lynette A} and Tesch, {Gregory H}",

year = "2009",

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T1 - Antibody blockade of c-fms suppresses the progression of inflammation and injury in early diabetic nephropathy in obese db/db mice

AU - Lim, Andy Kim Ho

AU - Ma, Frank

AU - Nicolic-Paterson, David

AU - Thomas, Merlin

AU - Hurst, Lynette A

AU - Tesch, Gregory H

PY - 2009

Y1 - 2009

N2 - Antibody blockade of c-fms suppresses the progression of inflammation and injury in early diabetic nephropathy in obese db/db mice. AIMS/HYPOTHESIS: Macrophage-mediated renal injury plays an important role in the development of diabetic nephropathy. Colony-stimulating factor (CSF)-1 is a cytokine that is produced in diabetic kidneys and promotes macrophage accumulation, activation and survival. CSF-1 acts exclusively through the c-fms receptor, which is only expressed on cells of the monocyte-macrophage lineage. Therefore, we used c-fms blockade as a strategy to selectively target macrophage-mediated injury during the progression of diabetic nephropathy.

AB - Antibody blockade of c-fms suppresses the progression of inflammation and injury in early diabetic nephropathy in obese db/db mice. AIMS/HYPOTHESIS: Macrophage-mediated renal injury plays an important role in the development of diabetic nephropathy. Colony-stimulating factor (CSF)-1 is a cytokine that is produced in diabetic kidneys and promotes macrophage accumulation, activation and survival. CSF-1 acts exclusively through the c-fms receptor, which is only expressed on cells of the monocyte-macrophage lineage. Therefore, we used c-fms blockade as a strategy to selectively target macrophage-mediated injury during the progression of diabetic nephropathy.

UR - http://www.springerlink.com/content/0360120kg778215j/

M3 - Article

SN - 0012-186X

VL - 52

SP - 1669

EP - 1679

JO - Diabetologia

JF - Diabetologia

IS - 8

ER -

Antibody blockade of c-fms suppresses the progression of inflammation and injury in early diabetic nephropathy in obese db/db mice

Abstract

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