Antibody blockade of c-fms suppresses the progression of inflammation and injury in early diabetic nephropathy in obese db/db mice

Andy Kim Ho Lim, Frank Ma, David Nicolic-Paterson, Merlin Thomas, Lynette A Hurst, Gregory H Tesch

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Abstract

Antibody blockade of c-fms suppresses the progression of inflammation and injury in early diabetic nephropathy in obese db/db mice. AIMS/HYPOTHESIS: Macrophage-mediated renal injury plays an important role in the development of diabetic nephropathy. Colony-stimulating factor (CSF)-1 is a cytokine that is produced in diabetic kidneys and promotes macrophage accumulation, activation and survival. CSF-1 acts exclusively through the c-fms receptor, which is only expressed on cells of the monocyte-macrophage lineage. Therefore, we used c-fms blockade as a strategy to selectively target macrophage-mediated injury during the progression of diabetic nephropathy.
Original languageEnglish
Pages (from-to)1669 - 1679
Number of pages11
JournalDiabetologia
Volume52
Issue number8
Publication statusPublished - 2009

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