Antibodies to Infectious Agents in Individuals at Ultra-High Risk for Psychosis

G. Paul Amminger, Patrick D. McGorry, Gregor E. Berger, Darryl Wade, Alison R. Yung, Lisa J. Phillips, Susy M. Harrigan, Shona M. Francey, Robert H. Yolken

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)

Abstract

Background: While there is evidence that some cases of schizophrenia may be associated with microbial infections, the role of microbial agents has not been investigated in people with emerging psychosis. Methods: Participants were 105 help seeking ultra-high risk individuals. Psychiatric measures included the Brief Psychiatric Rating Scale and the Scale for the Assessment of Negative Symptoms. Serum IgG antibodies against human herpesviruses and Toxoplasma gondii were determined using immunoassay methods. Multiple linear regression with adjustment for age and sex was applied to test associations between serum antibodies and psychiatric measures. Results: Higher levels of serum IgG antibodies against Toxoplasma gondii in Toxoplasma-positive individuals were significantly associated with more severe positive psychotic symptoms. No significant association was observed between antibody levels and psychiatric measures in individuals positive for human herpesviruses. Conclusions: In some individuals infection with Toxoplasma gondii may be an environmental factor contributing to the manifestation of positive psychotic symptoms.

Original languageEnglish
Pages (from-to)1215-1217
Number of pages3
JournalBiological Psychiatry
Volume61
Issue number10
DOIs
Publication statusPublished - 15 May 2007
Externally publishedYes

Keywords

  • Human herpes viruses
  • onset of psychosis
  • positive symptoms
  • schizophrenia
  • toxoplasma gondii
  • ultra-high risk

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