Antibodies to gp41 and nef in otherwise HIV-negative homosexual man with Kaposi's sarcoma

F. J. Bowden, S. Sonza, S. M. Crowe, D. A. McPhee, N. J. Deacon, S. A. Cumming, R. R. Doherty, C. R. Lucas

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)


A homosexual man with histologically confirmed Kaposi's sarcoma remained seronegative for HIV-1, HIV-2, and HTLV-I on conventional tests over a 4-year period. HIV cultures were also negative on thirteen separate occasions. However, serum antibodies to synthetic peptide analogues of the gp41 and nef regions of HIV-1 were consistently detected on an enzyme immunoassay. Tests with the polymerase chain reaction with primers directed to the gag and env regions were negative. The antigens to which the antibodies were produced might have come from a defective HIV mutant, another retrovirus, or a hitherto unknown "agent of Kaposi's sarcoma" with similar antigenic epitopes.

Original languageEnglish
Pages (from-to)1313-1314
Number of pages2
JournalThe Lancet
Issue number8753
Publication statusPublished - 1 Jun 1991
Externally publishedYes

Cite this