Antibodies specifically targeting a locally misfolded region of tumor associated EGFR

Thomas PJ Garrett; Anthony W Burgess; Hui K Gan; Rodney B Luwor; Glenn A Cartwright; Francesca Walker; Suzanne G Orchard; Andrew H A Clayton; Edouard C Nice; Julie Rothacker; Bruno Catimel; Webster K Cavenee; Lloyd J Old; Elisabeth Stockert; Gerd Ritter; Timothy E Adams; Peter A Hoyne; Dane Dane Wittrup; Ginger Chao; Jennifer R Cochran; Cindy S Luo; Mezhen Lou; Trevor Huyton; Yibin Xu; W Douglas Fairlie; Shenggen Yao; Andrew M Scott; Terrance Grant Johns

doi:10.1073/pnas.0811559106

Antibodies specifically targeting a locally misfolded region of tumor associated EGFR

Thomas PJ Garrett, Anthony W Burgess, Hui K Gan, Rodney B Luwor, Glenn A Cartwright, Francesca Walker, Suzanne G Orchard, Andrew H A Clayton, Edouard C Nice, Julie Rothacker, Bruno Catimel, Webster K Cavenee, Lloyd J Old, Elisabeth Stockert, Gerd Ritter, Timothy E Adams, Peter A Hoyne, Dane Dane Wittrup, Ginger Chao, Jennifer R CochranCindy S Luo, Mezhen Lou, Trevor Huyton, Yibin Xu, W Douglas Fairlie, Shenggen Yao, Andrew M Scott, Terrance Grant Johns

Hudson Institute - Centre for Cancer Research

Research output: Contribution to journal › Article › Research › peer-review

67 Citations (Scopus)

Abstract

Abstract Monoclonal antibodies (mAb s) and tyrosine kinase inhibitors targeting the Epidermal Growth Factor receptor (EGFR), which is often pathogenetically (over-)expressed or mutated in epithelial malignancies and glioma, have been modestly successful, with some approved for human use. MAb 806 was raised against de2-7EGFR (or EGFRvIII), a constitutively active mutation expressed in gliomas, but also recognizes a subset (

Original language	English
Pages (from-to)	5082 - 5087
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	106
Issue number	13
DOIs	https://doi.org/10.1073/pnas.0811559106
Publication status	Published - 2009

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Garrett, T. PJ., Burgess, A. W., Gan, H. K., Luwor, R. B., Cartwright, G. A., Walker, F., Orchard, S. G., Clayton, A. H. A., Nice, E. C., Rothacker, J., Catimel, B., Cavenee, W. K., Old, L. J., Stockert, E., Ritter, G., Adams, T. E., Hoyne, P. A., Wittrup, D. D., Chao, G., ... Johns, T. G. (2009). Antibodies specifically targeting a locally misfolded region of tumor associated EGFR. Proceedings of the National Academy of Sciences of the United States of America, 106(13), 5082 - 5087. https://doi.org/10.1073/pnas.0811559106

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title = "Antibodies specifically targeting a locally misfolded region of tumor associated EGFR",

abstract = "Abstract Monoclonal antibodies (mAb s) and tyrosine kinase inhibitors targeting the Epidermal Growth Factor receptor (EGFR), which is often pathogenetically (over-)expressed or mutated in epithelial malignancies and glioma, have been modestly successful, with some approved for human use. MAb 806 was raised against de2-7EGFR (or EGFRvIII), a constitutively active mutation expressed in gliomas, but also recognizes a subset (",

author = "Garrett, {Thomas PJ} and Burgess, {Anthony W} and Gan, {Hui K} and Luwor, {Rodney B} and Cartwright, {Glenn A} and Francesca Walker and Orchard, {Suzanne G} and Clayton, {Andrew H A} and Nice, {Edouard C} and Julie Rothacker and Bruno Catimel and Cavenee, {Webster K} and Old, {Lloyd J} and Elisabeth Stockert and Gerd Ritter and Adams, {Timothy E} and Hoyne, {Peter A} and Wittrup, {Dane Dane} and Ginger Chao and Cochran, {Jennifer R} and Luo, {Cindy S} and Mezhen Lou and Trevor Huyton and Yibin Xu and Fairlie, {W Douglas} and Shenggen Yao and Scott, {Andrew M} and Johns, {Terrance Grant}",

year = "2009",

doi = "10.1073/pnas.0811559106",

language = "English",

volume = "106",

pages = "5082 -- 5087",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

publisher = "National Academy of Sciences",

number = "13",

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Garrett, TPJ, Burgess, AW, Gan, HK, Luwor, RB, Cartwright, GA, Walker, F, Orchard, SG, Clayton, AHA, Nice, EC, Rothacker, J, Catimel, B, Cavenee, WK, Old, LJ, Stockert, E, Ritter, G, Adams, TE, Hoyne, PA, Wittrup, DD, Chao, G, Cochran, JR, Luo, CS, Lou, M, Huyton, T, Xu, Y, Fairlie, WD, Yao, S, Scott, AM & Johns, TG 2009, 'Antibodies specifically targeting a locally misfolded region of tumor associated EGFR', Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 13, pp. 5082 - 5087. https://doi.org/10.1073/pnas.0811559106

TY - JOUR

T1 - Antibodies specifically targeting a locally misfolded region of tumor associated EGFR

AU - Garrett, Thomas PJ

AU - Burgess, Anthony W

AU - Gan, Hui K

AU - Luwor, Rodney B

AU - Cartwright, Glenn A

AU - Walker, Francesca

AU - Orchard, Suzanne G

AU - Clayton, Andrew H A

AU - Nice, Edouard C

AU - Rothacker, Julie

AU - Catimel, Bruno

AU - Cavenee, Webster K

AU - Old, Lloyd J

AU - Stockert, Elisabeth

AU - Ritter, Gerd

AU - Adams, Timothy E

AU - Hoyne, Peter A

AU - Wittrup, Dane Dane

AU - Chao, Ginger

AU - Cochran, Jennifer R

AU - Luo, Cindy S

AU - Lou, Mezhen

AU - Huyton, Trevor

AU - Xu, Yibin

AU - Fairlie, W Douglas

AU - Yao, Shenggen

AU - Scott, Andrew M

AU - Johns, Terrance Grant

PY - 2009

Y1 - 2009

N2 - Abstract Monoclonal antibodies (mAb s) and tyrosine kinase inhibitors targeting the Epidermal Growth Factor receptor (EGFR), which is often pathogenetically (over-)expressed or mutated in epithelial malignancies and glioma, have been modestly successful, with some approved for human use. MAb 806 was raised against de2-7EGFR (or EGFRvIII), a constitutively active mutation expressed in gliomas, but also recognizes a subset (

AB - Abstract Monoclonal antibodies (mAb s) and tyrosine kinase inhibitors targeting the Epidermal Growth Factor receptor (EGFR), which is often pathogenetically (over-)expressed or mutated in epithelial malignancies and glioma, have been modestly successful, with some approved for human use. MAb 806 was raised against de2-7EGFR (or EGFRvIII), a constitutively active mutation expressed in gliomas, but also recognizes a subset (

UR - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656555/pdf/zpq5082.pdf

U2 - 10.1073/pnas.0811559106

DO - 10.1073/pnas.0811559106

M3 - Article

SN - 0027-8424

VL - 106

SP - 5082

EP - 5087

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 13

ER -

Antibodies specifically targeting a locally misfolded region of tumor associated EGFR

Abstract

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