Antibodies in the pathogenesis of hypertension

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14 Citations (Scopus)

Abstract

It has long been known that circulating levels of IgG and IgM antibodies are elevated in patients with essential and pregnancy-related hypertension. Recent studies indicate these antibodies target, and in many cases activate, G-protein coupled receptors and ion channels. Prominent among these protein targets are AT1 receptors, alpha 1-adrenoceptors, beta 1-adrenoceptors, and L-type voltage operated Ca2+ channels, all of which are known to play key roles in the regulation of blood pressure through modulation of vascular tone, cardiac output, and/or Na+/water reabsorption in the kidneys. This suggests that elevated antibody production may be a causal mechanism in at least some cases of hypertension. In this brief review, we will further describe the protein targets of the antibodies that are elevated in individuals with essential and pregnancy-related hypertension and the likely pathophysiological consequences of antibody binding to these targets. We will speculate on the potential mechanisms that underlie elevated antibody levels in hypertensive individuals and, finally, we will outline the therapeutic opportunities that could arise with a better understanding of how and why antibodies are produced in hypertension.
Original languageEnglish
Pages (from-to)1 - 9
Number of pages9
JournalBioMed Research International
Volume2014
Issue number(Art. No: 504045)
DOIs
Publication statusPublished - 2014

Cite this

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title = "Antibodies in the pathogenesis of hypertension",
abstract = "It has long been known that circulating levels of IgG and IgM antibodies are elevated in patients with essential and pregnancy-related hypertension. Recent studies indicate these antibodies target, and in many cases activate, G-protein coupled receptors and ion channels. Prominent among these protein targets are AT1 receptors, alpha 1-adrenoceptors, beta 1-adrenoceptors, and L-type voltage operated Ca2+ channels, all of which are known to play key roles in the regulation of blood pressure through modulation of vascular tone, cardiac output, and/or Na+/water reabsorption in the kidneys. This suggests that elevated antibody production may be a causal mechanism in at least some cases of hypertension. In this brief review, we will further describe the protein targets of the antibodies that are elevated in individuals with essential and pregnancy-related hypertension and the likely pathophysiological consequences of antibody binding to these targets. We will speculate on the potential mechanisms that underlie elevated antibody levels in hypertensive individuals and, finally, we will outline the therapeutic opportunities that could arise with a better understanding of how and why antibodies are produced in hypertension.",
author = "Christopher Chan and Maggie Lieu and Ban-Hock Toh and Kyaw, {Tin S} and Alexander Bobik and Sobey, {Christopher G} and Drummond, {Grant R}",
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Antibodies in the pathogenesis of hypertension. / Chan, Christopher; Lieu, Maggie; Toh, Ban-Hock; Kyaw, Tin S; Bobik, Alexander; Sobey, Christopher G; Drummond, Grant R.

In: BioMed Research International, Vol. 2014, No. (Art. No: 504045), 2014, p. 1 - 9.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Antibodies in the pathogenesis of hypertension

AU - Chan, Christopher

AU - Lieu, Maggie

AU - Toh, Ban-Hock

AU - Kyaw, Tin S

AU - Bobik, Alexander

AU - Sobey, Christopher G

AU - Drummond, Grant R

PY - 2014

Y1 - 2014

N2 - It has long been known that circulating levels of IgG and IgM antibodies are elevated in patients with essential and pregnancy-related hypertension. Recent studies indicate these antibodies target, and in many cases activate, G-protein coupled receptors and ion channels. Prominent among these protein targets are AT1 receptors, alpha 1-adrenoceptors, beta 1-adrenoceptors, and L-type voltage operated Ca2+ channels, all of which are known to play key roles in the regulation of blood pressure through modulation of vascular tone, cardiac output, and/or Na+/water reabsorption in the kidneys. This suggests that elevated antibody production may be a causal mechanism in at least some cases of hypertension. In this brief review, we will further describe the protein targets of the antibodies that are elevated in individuals with essential and pregnancy-related hypertension and the likely pathophysiological consequences of antibody binding to these targets. We will speculate on the potential mechanisms that underlie elevated antibody levels in hypertensive individuals and, finally, we will outline the therapeutic opportunities that could arise with a better understanding of how and why antibodies are produced in hypertension.

AB - It has long been known that circulating levels of IgG and IgM antibodies are elevated in patients with essential and pregnancy-related hypertension. Recent studies indicate these antibodies target, and in many cases activate, G-protein coupled receptors and ion channels. Prominent among these protein targets are AT1 receptors, alpha 1-adrenoceptors, beta 1-adrenoceptors, and L-type voltage operated Ca2+ channels, all of which are known to play key roles in the regulation of blood pressure through modulation of vascular tone, cardiac output, and/or Na+/water reabsorption in the kidneys. This suggests that elevated antibody production may be a causal mechanism in at least some cases of hypertension. In this brief review, we will further describe the protein targets of the antibodies that are elevated in individuals with essential and pregnancy-related hypertension and the likely pathophysiological consequences of antibody binding to these targets. We will speculate on the potential mechanisms that underlie elevated antibody levels in hypertensive individuals and, finally, we will outline the therapeutic opportunities that could arise with a better understanding of how and why antibodies are produced in hypertension.

UR - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090532/pdf/BMRI2014-504045.pdf

U2 - 10.1155/2014/504045

DO - 10.1155/2014/504045

M3 - Article

VL - 2014

SP - 1

EP - 9

JO - BioMed Research International

JF - BioMed Research International

SN - 2314-6133

IS - (Art. No: 504045)

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