Abstract
Covering: up to 2017 The overwhelming majority of antibiotics in clinical use originate from Gram-positive Actinobacteria. In recent years, however, Gram-negative bacteria have become increasingly recognised as a rich yet underexplored source of novel antimicrobials, with the potential to combat the looming health threat posed by antibiotic resistance. In this article, we have compiled a comprehensive list of natural products with antimicrobial activity from Gram-negative bacteria, including information on their biosynthetic origin(s) and molecular target(s), where known. We also provide a detailed discussion of several unusual pathways for antibiotic biosynthesis in Gram-negative bacteria, serving to highlight the exceptional biocatalytic repertoire of this group of microorganisms.
Original language | English |
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Pages (from-to) | 712-783 |
Number of pages | 72 |
Journal | Natural Product Reports |
Volume | 34 |
Issue number | 7 |
DOIs | |
Publication status | Published - 1 Jul 2017 |
Externally published | Yes |