Antibiotics from Gram-negative bacteria: A comprehensive overview and selected biosynthetic highlights

J. Masschelein, M. Jenner, G. L. Challis

Research output: Contribution to journalReview ArticleResearchpeer-review

47 Citations (Scopus)


Covering: up to 2017 The overwhelming majority of antibiotics in clinical use originate from Gram-positive Actinobacteria. In recent years, however, Gram-negative bacteria have become increasingly recognised as a rich yet underexplored source of novel antimicrobials, with the potential to combat the looming health threat posed by antibiotic resistance. In this article, we have compiled a comprehensive list of natural products with antimicrobial activity from Gram-negative bacteria, including information on their biosynthetic origin(s) and molecular target(s), where known. We also provide a detailed discussion of several unusual pathways for antibiotic biosynthesis in Gram-negative bacteria, serving to highlight the exceptional biocatalytic repertoire of this group of microorganisms.

Original languageEnglish
Pages (from-to)712-783
Number of pages72
JournalNatural Product Reports
Issue number7
Publication statusPublished - 1 Jul 2017
Externally publishedYes

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