Abstract
Clostridium perfringens is an anaerobic bacterium that is a major human and animal pathogen. The key features of C. perfringens-mediated infections are that disease pathogenesis involves the production of protein toxins and that disease epidemiology generally involves the production of environmentally resistant endospores. Many of the toxins involved in these diseases are encoded on conjugative plasmids that are closely related to the paradigm tetracycline resistance plasmid pCW3. This plasmid encodes the Tet(P) tetracycline resistance determinant, and the tcp locus, which mediates conjugative transfer and is also present on the toxin plasmids. In addition to being directly responsible for the widely dispersed distribution of the Tet(P) determinant, which is not located on a transposable genetic element, this family of conjugative plasmids facilitates the spread of other mobile resistance elements. These elements include the chloramphenicol resistance integrative mobilisable elements typified by Tn4451, the bacitracin resistance integrative conjugative element typified by ICECp1, and the lincomycin resistance transferable insertion sequence typified by tISCpe8. Each of these elements are found on conjugative plasmids that are closely related to pCW3, providing evidence that this large plasmid family has a key role in the distribution of antibiotic resistance genes in C. perfringens.
| Original language | English |
|---|---|
| Pages (from-to) | 32-39 |
| Number of pages | 8 |
| Journal | Plasmid |
| Volume | 99 |
| DOIs | |
| Publication status | Published - Sep 2018 |
Keywords
- Bacitracin resistance
- Chloramphenicol resistance
- Clostridium perfringens
- Lincomycin resistance
- Mobile genetic elements
- Tetracycline resistance
Cite this
}
Antibiotic resistance plasmids and mobile genetic elements of Clostridium perfringens. / Adams, Vicki; Han, Xiaoyan; Lyras, Dena; Rood, Julian I.
In: Plasmid, Vol. 99, 09.2018, p. 32-39.Research output: Contribution to journal › Review Article › Research › peer-review
TY - JOUR
T1 - Antibiotic resistance plasmids and mobile genetic elements of Clostridium perfringens
AU - Adams, Vicki
AU - Han, Xiaoyan
AU - Lyras, Dena
AU - Rood, Julian I.
PY - 2018/9
Y1 - 2018/9
N2 - Clostridium perfringens is an anaerobic bacterium that is a major human and animal pathogen. The key features of C. perfringens-mediated infections are that disease pathogenesis involves the production of protein toxins and that disease epidemiology generally involves the production of environmentally resistant endospores. Many of the toxins involved in these diseases are encoded on conjugative plasmids that are closely related to the paradigm tetracycline resistance plasmid pCW3. This plasmid encodes the Tet(P) tetracycline resistance determinant, and the tcp locus, which mediates conjugative transfer and is also present on the toxin plasmids. In addition to being directly responsible for the widely dispersed distribution of the Tet(P) determinant, which is not located on a transposable genetic element, this family of conjugative plasmids facilitates the spread of other mobile resistance elements. These elements include the chloramphenicol resistance integrative mobilisable elements typified by Tn4451, the bacitracin resistance integrative conjugative element typified by ICECp1, and the lincomycin resistance transferable insertion sequence typified by tISCpe8. Each of these elements are found on conjugative plasmids that are closely related to pCW3, providing evidence that this large plasmid family has a key role in the distribution of antibiotic resistance genes in C. perfringens.
AB - Clostridium perfringens is an anaerobic bacterium that is a major human and animal pathogen. The key features of C. perfringens-mediated infections are that disease pathogenesis involves the production of protein toxins and that disease epidemiology generally involves the production of environmentally resistant endospores. Many of the toxins involved in these diseases are encoded on conjugative plasmids that are closely related to the paradigm tetracycline resistance plasmid pCW3. This plasmid encodes the Tet(P) tetracycline resistance determinant, and the tcp locus, which mediates conjugative transfer and is also present on the toxin plasmids. In addition to being directly responsible for the widely dispersed distribution of the Tet(P) determinant, which is not located on a transposable genetic element, this family of conjugative plasmids facilitates the spread of other mobile resistance elements. These elements include the chloramphenicol resistance integrative mobilisable elements typified by Tn4451, the bacitracin resistance integrative conjugative element typified by ICECp1, and the lincomycin resistance transferable insertion sequence typified by tISCpe8. Each of these elements are found on conjugative plasmids that are closely related to pCW3, providing evidence that this large plasmid family has a key role in the distribution of antibiotic resistance genes in C. perfringens.
KW - Bacitracin resistance
KW - Chloramphenicol resistance
KW - Clostridium perfringens
KW - Lincomycin resistance
KW - Mobile genetic elements
KW - Tetracycline resistance
UR - http://www.scopus.com/inward/record.url?scp=85050618334&partnerID=8YFLogxK
U2 - 10.1016/j.plasmid.2018.07.002
DO - 10.1016/j.plasmid.2018.07.002
M3 - Review Article
VL - 99
SP - 32
EP - 39
JO - Plasmid
JF - Plasmid
SN - 0147-619X
ER -