Antibiotic-non-antibiotic combinations for combating extremely drug-resistant Gram-negative 'superbugs'

Elena K Schneider, Felisa Reyes Ortega, Tony Velkov, Jian Li

Research output: Contribution to journalReview ArticleResearchpeer-review

24 Citations (Scopus)

Abstract

The emergence of antimicrobial resistance of Gram-negative pathogens has become a worldwide crisis. The status quo for combating resistance is to employ synergistic combinations of antibiotics. Faced with this fast-approaching post-antibiotic era, it is critical that we devise strategies to prolong and maximize the clinical efficacy of existing antibiotics. Unfortunately, reports of extremely drug-resistant (XDR) Gram-negative pathogens have become more common. Combining antibiotics such as polymyxin B or the broad-spectrum tetracycline and minocycline with various FDA-approved non-antibiotic drugs have emerged as a novel combination strategy against otherwise untreatable XDR pathogens. This review surveys the available literature on the potential benefits of employing antibiotic-non-antibiotic drug combination therapy. The apex of this review highlights the clinical utility of this novel therapeutic strategy for combating infections caused by 'superbugs'.

Original languageEnglish
Pages (from-to)115-125
Number of pages11
JournalEssays in Biochemistry
Volume61
Issue number1
DOIs
Publication statusPublished - 3 Mar 2017

Cite this

Schneider, Elena K ; Reyes Ortega, Felisa ; Velkov, Tony ; Li, Jian. / Antibiotic-non-antibiotic combinations for combating extremely drug-resistant Gram-negative 'superbugs'. In: Essays in Biochemistry. 2017 ; Vol. 61, No. 1. pp. 115-125.
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Antibiotic-non-antibiotic combinations for combating extremely drug-resistant Gram-negative 'superbugs'. / Schneider, Elena K; Reyes Ortega, Felisa; Velkov, Tony; Li, Jian.

In: Essays in Biochemistry, Vol. 61, No. 1, 03.03.2017, p. 115-125.

Research output: Contribution to journalReview ArticleResearchpeer-review

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