Antibiotic consumption and chlamydia prevalence in international studies

Samitha Ginige, Marcus Y. Chen, Jane S. Hocking, Tim R H Read, Christopher K. Fairley

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Abstract

Background: To determine whether there is an ecological association between antibiotic use and chlamydia prevalence. Methods: A systematic review was undertaken of international studies on chlamydia prevalence among women aged 15-25 years published between 2000 and 2005. Preference was given to studies using nucleic acid testing and representative population-based sampling methods. Data were obtained on per capita antibiotic consumption according to the defined daily dose. Results: For the 12 countries for which both antibiotic consumption and relevant prevalence data for chlamydia were available, a non-significant negative correlation was found between total antibiotic consumption per capita and chlamydia prevalence among younger women according to country (rs = -0.242, P = 0.449). When an outlier (from the Netherlands) was excluded, the correlation was significant (rs = -0.615, P = 0.044). Combined use of tetracyclines and macrolides was also associated with lower chlamydia prevalence (rs = -0.697, P = 0.017). Conclusions: It is possible that antibiotics used for other reasons may have unexpectedly reduced the prevalence of chlamydia.

Original languageEnglish
Pages (from-to)221-224
Number of pages4
JournalSexual Health
Volume3
Issue number4
DOIs
Publication statusPublished - 24 Nov 2006

Cite this

Ginige, Samitha ; Chen, Marcus Y. ; Hocking, Jane S. ; Read, Tim R H ; Fairley, Christopher K. / Antibiotic consumption and chlamydia prevalence in international studies. In: Sexual Health. 2006 ; Vol. 3, No. 4. pp. 221-224.
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Antibiotic consumption and chlamydia prevalence in international studies. / Ginige, Samitha; Chen, Marcus Y.; Hocking, Jane S.; Read, Tim R H; Fairley, Christopher K.

In: Sexual Health, Vol. 3, No. 4, 24.11.2006, p. 221-224.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Ginige, Samitha

AU - Chen, Marcus Y.

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AU - Read, Tim R H

AU - Fairley, Christopher K.

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N2 - Background: To determine whether there is an ecological association between antibiotic use and chlamydia prevalence. Methods: A systematic review was undertaken of international studies on chlamydia prevalence among women aged 15-25 years published between 2000 and 2005. Preference was given to studies using nucleic acid testing and representative population-based sampling methods. Data were obtained on per capita antibiotic consumption according to the defined daily dose. Results: For the 12 countries for which both antibiotic consumption and relevant prevalence data for chlamydia were available, a non-significant negative correlation was found between total antibiotic consumption per capita and chlamydia prevalence among younger women according to country (rs = -0.242, P = 0.449). When an outlier (from the Netherlands) was excluded, the correlation was significant (rs = -0.615, P = 0.044). Combined use of tetracyclines and macrolides was also associated with lower chlamydia prevalence (rs = -0.697, P = 0.017). Conclusions: It is possible that antibiotics used for other reasons may have unexpectedly reduced the prevalence of chlamydia.

AB - Background: To determine whether there is an ecological association between antibiotic use and chlamydia prevalence. Methods: A systematic review was undertaken of international studies on chlamydia prevalence among women aged 15-25 years published between 2000 and 2005. Preference was given to studies using nucleic acid testing and representative population-based sampling methods. Data were obtained on per capita antibiotic consumption according to the defined daily dose. Results: For the 12 countries for which both antibiotic consumption and relevant prevalence data for chlamydia were available, a non-significant negative correlation was found between total antibiotic consumption per capita and chlamydia prevalence among younger women according to country (rs = -0.242, P = 0.449). When an outlier (from the Netherlands) was excluded, the correlation was significant (rs = -0.615, P = 0.044). Combined use of tetracyclines and macrolides was also associated with lower chlamydia prevalence (rs = -0.697, P = 0.017). Conclusions: It is possible that antibiotics used for other reasons may have unexpectedly reduced the prevalence of chlamydia.

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