Antibacterial poly(ethylene glycol) hydrogels from combined epoxy-amine and thiol-ene click reaction

Chao Zhou; Vinh X. Truong; Yue Qu; Trevor Lithgow; Guodong Fu; John S. Forsythe

doi:10.1002/pola.27886

Antibacterial poly(ethylene glycol) hydrogels from combined epoxy-amine and thiol-ene click reaction

Chao Zhou, Vinh X. Truong, Yue Qu, Trevor Lithgow, Guodong Fu, John S. Forsythe

Research output: Contribution to journal › Article › Research › peer-review

36 Citations (Scopus)

Abstract

Antibacterial hydrogels containing quaternary ammonium (QA) groups were prepared via a facile thiolene "click” reaction using multifunctional poly(ethylene glycol) (PEG). The multifunctional PEG polymers were prepared by an epoxy-amine ring opening reaction. The chemical and physical properties of the hydrogels could be tuned with different crosslinking structures and crosslinking densities. The antibacterial hydrogel structures prepared from PEG Pendant QA were less well-defined than those from PEG Chain-End QA. Furthermore, functionalization of the PEG-type hydrogels with QA groups produced strong antibacterial abilities against Staphylococcus aureus, and therefore has the potential to be used as an antiinfective material for biomedical devices.

Original language	English
Pages (from-to)	656 - 667
Number of pages	12
Journal	Journal of Polymer Science, Part A: Polymer Chemistry
Volume	54
Issue number	5
DOIs	https://doi.org/10.1002/pola.27886
Publication status	Published - 2016

Keywords

Antibacterial hydrogel
Epoxy-amine ring opening reaction
Quatemary ammonium
Thiol-ene click chemistry

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title = "Antibacterial poly(ethylene glycol) hydrogels from combined epoxy-amine and thiol-ene click reaction",

abstract = "Antibacterial hydrogels containing quaternary ammonium (QA) groups were prepared via a facile thiolene {"}click” reaction using multifunctional poly(ethylene glycol) (PEG). The multifunctional PEG polymers were prepared by an epoxy-amine ring opening reaction. The chemical and physical properties of the hydrogels could be tuned with different crosslinking structures and crosslinking densities. The antibacterial hydrogel structures prepared from PEG Pendant QA were less well-defined than those from PEG Chain-End QA. Furthermore, functionalization of the PEG-type hydrogels with QA groups produced strong antibacterial abilities against Staphylococcus aureus, and therefore has the potential to be used as an antiinfective material for biomedical devices. ",

keywords = "Antibacterial hydrogel, Epoxy-amine ring opening reaction, Quatemary ammonium, Thiol-ene click chemistry",

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T1 - Antibacterial poly(ethylene glycol) hydrogels from combined epoxy-amine and thiol-ene click reaction

AU - Zhou, Chao

AU - Truong, Vinh X.

AU - Qu, Yue

AU - Lithgow, Trevor

AU - Fu, Guodong

AU - Forsythe, John S.

PY - 2016

Y1 - 2016

N2 - Antibacterial hydrogels containing quaternary ammonium (QA) groups were prepared via a facile thiolene "click” reaction using multifunctional poly(ethylene glycol) (PEG). The multifunctional PEG polymers were prepared by an epoxy-amine ring opening reaction. The chemical and physical properties of the hydrogels could be tuned with different crosslinking structures and crosslinking densities. The antibacterial hydrogel structures prepared from PEG Pendant QA were less well-defined than those from PEG Chain-End QA. Furthermore, functionalization of the PEG-type hydrogels with QA groups produced strong antibacterial abilities against Staphylococcus aureus, and therefore has the potential to be used as an antiinfective material for biomedical devices.

AB - Antibacterial hydrogels containing quaternary ammonium (QA) groups were prepared via a facile thiolene "click” reaction using multifunctional poly(ethylene glycol) (PEG). The multifunctional PEG polymers were prepared by an epoxy-amine ring opening reaction. The chemical and physical properties of the hydrogels could be tuned with different crosslinking structures and crosslinking densities. The antibacterial hydrogel structures prepared from PEG Pendant QA were less well-defined than those from PEG Chain-End QA. Furthermore, functionalization of the PEG-type hydrogels with QA groups produced strong antibacterial abilities against Staphylococcus aureus, and therefore has the potential to be used as an antiinfective material for biomedical devices.

KW - Antibacterial hydrogel

KW - Epoxy-amine ring opening reaction

KW - Quatemary ammonium

KW - Thiol-ene click chemistry

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DO - 10.1002/pola.27886

M3 - Article

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JO - Journal of Polymer Science, Part A: Polymer Chemistry

JF - Journal of Polymer Science, Part A: Polymer Chemistry

IS - 5

ER -

Antibacterial poly(ethylene glycol) hydrogels from combined epoxy-amine and thiol-ene click reaction

Abstract

Keywords

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