Antibacterial poly(ethylene glycol) hydrogels from combined epoxy-amine and thiol-ene click reaction

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Antibacterial hydrogels containing quaternary ammonium (QA) groups were prepared via a facile thiolene "click” reaction using multifunctional poly(ethylene glycol) (PEG). The multifunctional PEG polymers were prepared by an epoxy-amine ring opening reaction. The chemical and physical properties of the hydrogels could be tuned with different crosslinking structures and crosslinking densities. The antibacterial hydrogel structures prepared from PEG Pendant QA were less well-defined than those from PEG Chain-End QA. Furthermore, functionalization of the PEG-type hydrogels with QA groups produced strong antibacterial abilities against Staphylococcus aureus, and therefore has the potential to be used as an antiinfective material for biomedical devices.
Original languageEnglish
Pages (from-to)656 - 667
Number of pages12
JournalJournal of Polymer Science, Part A: Polymer Chemistry
Volume54
Issue number5
DOIs
Publication statusPublished - 2016

Keywords

  • Antibacterial hydrogel
  • Epoxy-amine ring opening reaction
  • Quatemary ammonium
  • Thiol-ene click chemistry

Cite this

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title = "Antibacterial poly(ethylene glycol) hydrogels from combined epoxy-amine and thiol-ene click reaction",
abstract = "Antibacterial hydrogels containing quaternary ammonium (QA) groups were prepared via a facile thiolene {"}click” reaction using multifunctional poly(ethylene glycol) (PEG). The multifunctional PEG polymers were prepared by an epoxy-amine ring opening reaction. The chemical and physical properties of the hydrogels could be tuned with different crosslinking structures and crosslinking densities. The antibacterial hydrogel structures prepared from PEG Pendant QA were less well-defined than those from PEG Chain-End QA. Furthermore, functionalization of the PEG-type hydrogels with QA groups produced strong antibacterial abilities against Staphylococcus aureus, and therefore has the potential to be used as an antiinfective material for biomedical devices.",
keywords = "Antibacterial hydrogel, Epoxy-amine ring opening reaction, Quatemary ammonium, Thiol-ene click chemistry",
author = "Chao Zhou and Truong, {Vinh X.} and Yue Qu and Trevor Lithgow and Guodong Fu and Forsythe, {John S.}",
year = "2016",
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journal = "Journal of Polymer Science, Part A: Polymer Chemistry",
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Antibacterial poly(ethylene glycol) hydrogels from combined epoxy-amine and thiol-ene click reaction. / Zhou, Chao; Truong, Vinh X.; Qu, Yue; Lithgow, Trevor; Fu, Guodong; Forsythe, John S.

In: Journal of Polymer Science, Part A: Polymer Chemistry, Vol. 54, No. 5, 2016, p. 656 - 667.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Antibacterial poly(ethylene glycol) hydrogels from combined epoxy-amine and thiol-ene click reaction

AU - Zhou, Chao

AU - Truong, Vinh X.

AU - Qu, Yue

AU - Lithgow, Trevor

AU - Fu, Guodong

AU - Forsythe, John S.

PY - 2016

Y1 - 2016

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AB - Antibacterial hydrogels containing quaternary ammonium (QA) groups were prepared via a facile thiolene "click” reaction using multifunctional poly(ethylene glycol) (PEG). The multifunctional PEG polymers were prepared by an epoxy-amine ring opening reaction. The chemical and physical properties of the hydrogels could be tuned with different crosslinking structures and crosslinking densities. The antibacterial hydrogel structures prepared from PEG Pendant QA were less well-defined than those from PEG Chain-End QA. Furthermore, functionalization of the PEG-type hydrogels with QA groups produced strong antibacterial abilities against Staphylococcus aureus, and therefore has the potential to be used as an antiinfective material for biomedical devices.

KW - Antibacterial hydrogel

KW - Epoxy-amine ring opening reaction

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