Antibacterial poly(ethylene glycol) hydrogels from combined epoxy-amine and thiol-ene click reaction

Chao Zhou, Vinh X. Truong, Yue Qu, Trevor Lithgow, Guodong Fu, John S. Forsythe

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)


Antibacterial hydrogels containing quaternary ammonium (QA) groups were prepared via a facile thiolene "click” reaction using multifunctional poly(ethylene glycol) (PEG). The multifunctional PEG polymers were prepared by an epoxy-amine ring opening reaction. The chemical and physical properties of the hydrogels could be tuned with different crosslinking structures and crosslinking densities. The antibacterial hydrogel structures prepared from PEG Pendant QA were less well-defined than those from PEG Chain-End QA. Furthermore, functionalization of the PEG-type hydrogels with QA groups produced strong antibacterial abilities against Staphylococcus aureus, and therefore has the potential to be used as an antiinfective material for biomedical devices.
Original languageEnglish
Pages (from-to)656 - 667
Number of pages12
JournalJournal of Polymer Science, Part A: Polymer Chemistry
Issue number5
Publication statusPublished - 2016


  • Antibacterial hydrogel
  • Epoxy-amine ring opening reaction
  • Quatemary ammonium
  • Thiol-ene click chemistry

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