Antibacterial applications of silver nanoparticles: Benefits and human health risks

Renat R. Khaydarov, Rashid A. Khaydarov, Yuri Estrin, Svetlana Evgrafova, Seung Y. Cho, Stefanie Wagner

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Research


The minimum inhibitory concentrations (MICs) assays conducted for E. coli, S. aureus, B. subtilis and P. phoeniceum have shown that the antimicrobial activity of silver ions was superior to that of silver nanoparticles. As silver nanoparticles can be more suitable in some bactericidal applications than silver ions, the efficacy of nanosilver as an antimicrobial agent against a range of microbes on the surface of water paints and cotton fabrics has been studied. The cytotoxicity of silver nanoparticles has been studied using NIH-3T3, HEP-G2, A-549, PC-12, and Colo-320 cells via the MTT ((3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium-bromid) test. The MTT test results obtained have shown that silver nanoparticles in concentrations of ~1-10 ppm entering the body from air or liquid suspensions can present a potential risk to human health. However, silver nanoparticles as a commercially viable addition to be used in paint and textile industry are unlikely to present a direct health risk.

Original languageEnglish
Title of host publicationSilver Nanoparticles
Subtitle of host publicationProperties, Characterization and Applications
EditorsAudrey E. Wells
Place of PublicationNew York NY USA
PublisherNova Science Publishers
Number of pages13
ISBN (Print)9781616686901
Publication statusPublished - 2010

Publication series

NameNanotechnology Science and Technology
PublisherNova Science Publishers


  • Cytotoxicity
  • Eucaryota
  • Health risk
  • Nanoparticle
  • Silver
  • Silver ion

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