Anti-quorum sensing and antibiotic enhancement of allylpyrocatechol and methyl gallate

Carine S.S. Lim; C. W. Wong; Joash B.L. Tan; V. S. Anggraeni; Z. J. Loong; Y. K. Teo

doi:10.11113/JURNALTEKNOLOGI.V83.15146

Anti-quorum sensing and antibiotic enhancement of allylpyrocatechol and methyl gallate

Carine S.S. Lim, C. W. Wong, Joash B.L. Tan, V. S. Anggraeni, Z. J. Loong, Y. K. Teo

Malaysia Sch of Science

Research output: Contribution to journal › Article › Research › peer-review

5 Citations (Scopus)

Abstract

In this study, the antibiotic enhancement and quorum sensing (QS) inhibition of allylpyrocatechol (APC) and methyl gallate (MG) isolated from leaves of Piper betle (betel) and leaf shoots of Anacardium occidentale (cashew), respectively, were compared. When applied with streptomycin and tested against Staphylococcus aureus and Pseudomonas aeruginosa, the effect of APC was additive while that of MG was synergistic. In terms of QS inhibition against Chromobacterium violaceum, both compounds were equally effective with violacein inhibition observed at concentrations of 60 μg/mL. We successfully increased the purity of APC in the methanol betel leaf extract from 13.2% to 31.5% w/w through solvent partitioning. This study is the first to document the anti-QS activity of APC, which is comparable to that of MG.

Original language	English
Pages (from-to)	101-106
Number of pages	6
Journal	Jurnal Teknologi
Volume	83
Issue number	3
DOIs	https://doi.org/10.11113/JURNALTEKNOLOGI.V83.15146
Publication status	Published - May 2021

Keywords

Allylpyrocatechol
Anacardium occidentale
Antibiotic enhancement
Methyl gallate
Piper betle
Quorum sensing inhibition

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title = "Anti-quorum sensing and antibiotic enhancement of allylpyrocatechol and methyl gallate",

abstract = "In this study, the antibiotic enhancement and quorum sensing (QS) inhibition of allylpyrocatechol (APC) and methyl gallate (MG) isolated from leaves of Piper betle (betel) and leaf shoots of Anacardium occidentale (cashew), respectively, were compared. When applied with streptomycin and tested against Staphylococcus aureus and Pseudomonas aeruginosa, the effect of APC was additive while that of MG was synergistic. In terms of QS inhibition against Chromobacterium violaceum, both compounds were equally effective with violacein inhibition observed at concentrations of 60 μg/mL. We successfully increased the purity of APC in the methanol betel leaf extract from 13.2% to 31.5% w/w through solvent partitioning. This study is the first to document the anti-QS activity of APC, which is comparable to that of MG.",

keywords = "Allylpyrocatechol, Anacardium occidentale, Antibiotic enhancement, Methyl gallate, Piper betle, Quorum sensing inhibition",

author = "Lim, {Carine S.S.} and Wong, {C. W.} and Tan, {Joash B.L.} and Anggraeni, {V. S.} and Loong, {Z. J.} and Teo, {Y. K.}",

note = "Funding Information: The authors are thankful to UCSI University for providing a research grant (REIG-FAS-2020/027) in support of this study. The laboratory facilities and technical assistance of the Faculty of Applied Sciences are acknowledged with gratitude. Publisher Copyright: {\textcopyright} 2021 Penerbit UTM Press. All rights reserved.",

year = "2021",

month = may,

doi = "10.11113/JURNALTEKNOLOGI.V83.15146",

language = "English",

volume = "83",

pages = "101--106",

journal = "Jurnal Teknologi",

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T1 - Anti-quorum sensing and antibiotic enhancement of allylpyrocatechol and methyl gallate

AU - Lim, Carine S.S.

AU - Wong, C. W.

AU - Tan, Joash B.L.

AU - Anggraeni, V. S.

AU - Loong, Z. J.

AU - Teo, Y. K.

N1 - Funding Information: The authors are thankful to UCSI University for providing a research grant (REIG-FAS-2020/027) in support of this study. The laboratory facilities and technical assistance of the Faculty of Applied Sciences are acknowledged with gratitude. Publisher Copyright: © 2021 Penerbit UTM Press. All rights reserved.

PY - 2021/5

Y1 - 2021/5

N2 - In this study, the antibiotic enhancement and quorum sensing (QS) inhibition of allylpyrocatechol (APC) and methyl gallate (MG) isolated from leaves of Piper betle (betel) and leaf shoots of Anacardium occidentale (cashew), respectively, were compared. When applied with streptomycin and tested against Staphylococcus aureus and Pseudomonas aeruginosa, the effect of APC was additive while that of MG was synergistic. In terms of QS inhibition against Chromobacterium violaceum, both compounds were equally effective with violacein inhibition observed at concentrations of 60 μg/mL. We successfully increased the purity of APC in the methanol betel leaf extract from 13.2% to 31.5% w/w through solvent partitioning. This study is the first to document the anti-QS activity of APC, which is comparable to that of MG.

AB - In this study, the antibiotic enhancement and quorum sensing (QS) inhibition of allylpyrocatechol (APC) and methyl gallate (MG) isolated from leaves of Piper betle (betel) and leaf shoots of Anacardium occidentale (cashew), respectively, were compared. When applied with streptomycin and tested against Staphylococcus aureus and Pseudomonas aeruginosa, the effect of APC was additive while that of MG was synergistic. In terms of QS inhibition against Chromobacterium violaceum, both compounds were equally effective with violacein inhibition observed at concentrations of 60 μg/mL. We successfully increased the purity of APC in the methanol betel leaf extract from 13.2% to 31.5% w/w through solvent partitioning. This study is the first to document the anti-QS activity of APC, which is comparable to that of MG.

KW - Allylpyrocatechol

KW - Anacardium occidentale

KW - Antibiotic enhancement

KW - Methyl gallate

KW - Piper betle

KW - Quorum sensing inhibition

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U2 - 10.11113/JURNALTEKNOLOGI.V83.15146

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SN - 0127-9696

VL - 83

SP - 101

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JO - Jurnal Teknologi

JF - Jurnal Teknologi

IS - 3

ER -

Anti-quorum sensing and antibiotic enhancement of allylpyrocatechol and methyl gallate

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