TY - JOUR
T1 - Anti-Müllerian Hormone in PCOS
T2 - A Review Informing International Guidelines
AU - Teede, Helena
AU - Misso, Marie
AU - Tassone, Eliza C.
AU - Dewailly, Didier
AU - Ng, Ernest Hy
AU - Azziz, Ricardo
AU - Norman, Robert J.
AU - Andersen, Marianne
AU - Franks, Stephen
AU - Hoeger, Kathleen
AU - Hutchison, Samantha
AU - Oberfield, Sharon
AU - Shah, Duru
AU - Hohmann, Femke
AU - Ottey, Sasha
AU - Dabadghao, Preeti
AU - Laven, Joop S.E.
PY - 2019/7
Y1 - 2019/7
N2 - Polycystic ovary syndrome (PCOS) affects 8–13% of women. The Rotterdam diagnostic criteria include polycystic ovarian morphology (PCOM) on ultrasound, but given recognized challenges, serum anti-Müllerian hormone (AMH) is proposed as an alternative. To inform international PCOS guidelines, a systematic review was completed. Key identified gaps include large international studies in well-defined populations across the lifespan, clustering of AMH with PCOS features, relationships to long-term health outcomes, and improved quality, assay standardization, and sample handling, all needed to determine cut offs. Here we identify research priorities to address these gaps and enhance AMH utility in PCOS. Once issues are addressed, AMH levels could replace more costly and less accessible ultrasound in PCOS diagnosis.
AB - Polycystic ovary syndrome (PCOS) affects 8–13% of women. The Rotterdam diagnostic criteria include polycystic ovarian morphology (PCOM) on ultrasound, but given recognized challenges, serum anti-Müllerian hormone (AMH) is proposed as an alternative. To inform international PCOS guidelines, a systematic review was completed. Key identified gaps include large international studies in well-defined populations across the lifespan, clustering of AMH with PCOS features, relationships to long-term health outcomes, and improved quality, assay standardization, and sample handling, all needed to determine cut offs. Here we identify research priorities to address these gaps and enhance AMH utility in PCOS. Once issues are addressed, AMH levels could replace more costly and less accessible ultrasound in PCOS diagnosis.
KW - adolescent
KW - adult
KW - anti-Müllerian hormone
KW - diagnostic accuracy
KW - polycystic ovary syndrome
KW - review
UR - https://www.scopus.com/pages/publications/85066313394
U2 - 10.1016/j.tem.2019.04.006
DO - 10.1016/j.tem.2019.04.006
M3 - Review Article
C2 - 31160167
AN - SCOPUS:85066313394
SN - 1043-2760
VL - 30
SP - 467
EP - 478
JO - Trends in Endocrinology & Metabolism
JF - Trends in Endocrinology & Metabolism
IS - 7
ER -
