Anti-Müllerian Hormone in PCOS: A Review Informing International Guidelines

Helena Teede, Marie Misso, Eliza C. Tassone, Didier Dewailly, Ernest Hy Ng, Ricardo Azziz, Robert J. Norman, Marianne Andersen, Stephen Franks, Kathleen Hoeger, Samantha Hutchison, Sharon Oberfield, Duru Shah, Femke Hohmann, Sasha Ottey, Preeti Dabadghao, Joop S.E. Laven

Research output: Contribution to journalReview ArticleResearchpeer-review

12 Citations (Scopus)

Abstract

Polycystic ovary syndrome (PCOS) affects 8–13% of women. The Rotterdam diagnostic criteria include polycystic ovarian morphology (PCOM) on ultrasound, but given recognized challenges, serum anti-Müllerian hormone (AMH) is proposed as an alternative. To inform international PCOS guidelines, a systematic review was completed. Key identified gaps include large international studies in well-defined populations across the lifespan, clustering of AMH with PCOS features, relationships to long-term health outcomes, and improved quality, assay standardization, and sample handling, all needed to determine cut offs. Here we identify research priorities to address these gaps and enhance AMH utility in PCOS. Once issues are addressed, AMH levels could replace more costly and less accessible ultrasound in PCOS diagnosis.

Original languageEnglish
Pages (from-to)467-478
Number of pages12
JournalTrends in Endocrinology and Metabolism
Volume30
Issue number7
DOIs
Publication statusPublished - Jul 2019

Keywords

  • adolescent
  • adult
  • anti-Müllerian hormone
  • diagnostic accuracy
  • polycystic ovary syndrome
  • review

Cite this

Teede, H., Misso, M., Tassone, E. C., Dewailly, D., Ng, E. H., Azziz, R., Norman, R. J., Andersen, M., Franks, S., Hoeger, K., Hutchison, S., Oberfield, S., Shah, D., Hohmann, F., Ottey, S., Dabadghao, P., & Laven, J. S. E. (2019). Anti-Müllerian Hormone in PCOS: A Review Informing International Guidelines. Trends in Endocrinology and Metabolism, 30(7), 467-478. https://doi.org/10.1016/j.tem.2019.04.006